The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that PV-immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling. In vitro, pemphigus IgG caused typical hallmarks of pemphigus pathogenesis such as epidermal blister...

Pemphigus vulgaris is an autoimmune blistering disease that commonly involves the scalp. Lesions of pemphigus vulgaris that persist on the scalp for a long period may be accompanied by tufted hair folliculitis. Only two previous accounts of tufted hair folliculitis developing in a lesion of pemphigus vulgaris have been reported. We report a 51-year-old-man with erosions and clusters of hair on ...

INTRODUCTION Pemphigus vulgaris (PV) is a chronic and infrequent autoimmune mucocutaneous disease that is characterized by the loose blisters and erosions on the skin and mucous membrane. Middle-aged adults are affect most frequently and the elderly and juvenile cases are infrequent. Herein, we reported a case of pemphigus vulgaris in an elderly patient. CASE PRESENTATION We reported a case o...

COOPER (1858) first described the ocular manifestations of pemphigus. von Kries (1878), working in von Graefe's clinic, described "essential shrinkage of the conjunctiva", and von Graefe (1879) identified the terminal state of pemphigus with essential shrinkage of the conjunctiva. By 1892, when Duane translated Fuchs's textbook into English, the diagnosis of pemphigus conjunctivae was establish...

diseases and is divided into two vulgaris and foliaceus pemphigus and mainly appears during fifties and sixties.1,2 Its etiology is not exactly known and genetic talent may play a role in its development.3,4 The disease is globally widespread and is more common in some races.5,6 A study was conducted to evaluate the HLA-class I in patients suffering from pemphigus. Patients with skin biopsy of ...

pemphigus vulgaris (pv) is an autoimmune blistering disorder of the skin or mucosa. since low vitamin d status has been linked to many immune disorders, we designed this study to compare the vitamin d status in pv patients with healthy controls.in this case-control study, vitamin d status of 32 newly diagnosed pv patients was compared with 36 healthy control subjects. all patients were selected...

Background: Pemphigus is a serious blistering disease with considerable mortality, which heavily burdens on health care system because of the long time hospitalization. It is rare in north America but is considered as the most common immunobullous disease in eastern countries such as Malaysia and China. Objective: The purpose of this study was to define the epidemiologic features of pemph...

Pemphigus consists of a group of chronic blistering skin diseases mediated by autoantibodies (autoAbs). The dogma that pemphigus is caused by keratinocyte dissociation (acantholysis) as a distinctive and direct consequence of the presence of autoAb targeting two main proteins of the desmosome-desmoglein (DSG) 1 and/or DSG3-has been put to the test. Several outside-in signaling events elicited b...