Better understanding of the biophysical and biochemical cues of the tumor extracellular matrix environment that influence metastasis may have important implications for new cancer therapeutics. Initial exploration into this question has used naturally derived protein matrices that suffer from variability, poor control over matrix biochemistry, and inability to modify the matrix biochemistry and...

The catabolism of streptokinase (SK) and polyethylene glycol derivatives of SK (PEG-SK) were studied in mice. The clearance and catabolism of SK:plasmin (SK:Pm) and PEG-SK:Pm activator complexes were also investigated. Native 125I-SK cleared rapidly (t1/2 = 15 minutes) from the circulation, with the majority of the ligand accumulating in the liver and gastrointestinal (GI) tract and a substanti...

The present work concerns on the investigation of the role of polyethylene glycols (PEGs) as masking agent for amelioration of extraction-separation of La(III), Eu(III) and Er(III) ions by the acidic extractant bis(2-ethylhexyl)phosphoric acid (DEHPA). The studied solvent extraction system is based on the combination of chelating effect of DEHPA in the organic phase on the one hand, and the bin...

somatic embryos of persian walnut were transformed with two strains of agrobacterium tumefaciens i.e. lba4404 and c58, and two plasmids, namely, pbi121 with nptii and gus genes for improving the transformation protocol, and p6u-ubi-fvti plasmid containing the hpt and fld genes. the transformation frequency was 10%. pcr and rt-pcr analysis proved the presence and expression of the genes. the tra...

conclusions there was no significant lower recurrence rate of constipation with peg and lactulose combination therapy over peg alone. therefore, changing treatment from lactulose plus peg to peg alone would result in better compliance of patients for long-term therapy and would be cost effective. results the response rate to treatment was 70% in group i and 87% in group ii (p value 0.003). recu...

Objective(s): The wide scale use of Zinc oxide nanoparticles (ZnO NPs) in the consumer market world makes human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. Therefore, the aim of the present study is to assess renal toxicity potential of ZnO and Polyethylene glycol Coated ZnO Nanoparticles in rat.Materials and Methods: Co-precipitation chemical method was used...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...