BACKGROUND Protein profiling with high-throughput sample preparation and MALDI-TOF MS analysis is a new potential tool for diagnosis of human diseases. However, analytical reproducibility is a significant challenge in MALDI protein profiling. This minireview summarizes studies of reproducibility of MALDI protein profiling and current approaches to improve its analytical performance. METHODS T...

The purpose of this study was (1) to determine if overweight/obese individuals (age 26-50 y) would self-select moderate exercise intensity when asked to do so and (2) to determine how this self-selected workload compared to exercising at a workload (60% peak aerobic capacity) that is known to provide cardioprotective health benefits. Oxygen consumption (VO(2)) and energy expenditure were measur...

The traditional warm-up (WU) used by athletes to prepare for a sprint track cycling event involves a general WU followed by a series of brief sprints lasting ≥ 50 min in total. A WU of this duration and intensity could cause significant fatigue and impair subsequent performance. The purpose of this research was to compare a traditional WU with an experimental WU and examine the consequences of ...

Least-squares fitting of overlapping peaks is often needed to separately quantify ions in high-resolution mass spectrometer data. A statistical simulation approach is used to assess the statistical precision of the retrieved peak intensities. The sensitivity of the fitted peak intensities to statistical noise due to ion counting is probed for synthetic data systems consisting of two overlapping...

The responses of rabbit rods to light were studied by drawing a single rod outer segment projecting from a small piece of retina into a glass pipette to record membrane current. The bath solution around the cells was maintained at near 40 degrees C. Light flashes evoked transient outward currents that saturated at up to approximately 20 pA. One absorbed photon produced a response of approximate...

Mean values for two variables of the pubertal growth spurt, peak height velocity and age at peak velocity, of children attending the diabetic clinic in Bristol are reported. The growth spurt was normal both in timing and intensity in boys, but the peak velocity was reduced and age at peak velocity more variable among girls.

in this report, we present a facile approach for the synthesis of luminescent cds and cds:mn+2 nanocrystals by reaction of cdso4 and na2s2o3 in the presence of thioglycerol (c3h8o2s) as capping agent. the influence of various experimental variables including, ph values and percentage of dopant, on the growth rate and optical properties of the obtained cds nanocrystals has been systematically in...

We show that graphene deposited on a substrate has a non-negligible density of atomic scale defects. This is evidenced by a previously unnoticed D peak in the Raman spectra with intensity of ∼1% with respect to the G peak. We evaluated the effect of such impurities on electron transport by mimicking them with hydrogen adsorbates and measuring the induced changes in both mobility and Raman inten...

We report on a new click type found in Mangetti Dune !Xung (M.D. !Xung) a forward released denti-alveolar lateral click, transcribed [ ||| ]. We present acoustic data showing that ||| is distinct from the "typical" lateral (post-) alveolar ||, and the central (post-) alveolar !, a conclusion supported by synchronic and diachronic analyses of Northern Khoisan [8, 12]. We use Adaptive Dispersion ...