BACKGROUND The haptic perception of the curvature of an object is essential for adequate object manipulation and critical for our guidance of actions. This study investigated how the ability to perceive the curvature of an object is altered by Parkinson's disease (PD). METHODOLOGY/PRINCIPAL FINDINGS Eight healthy subjects and 11 patients with mild to moderate PD had to judge, without vision, ...

OBJECTIVE To determine the effects of participation in a 2-year community-based dance class on disease severity and functional mobility in people with Parkinson disease (PD). DESIGN Randomized controlled trial. SETTINGS/LOCATION Dance classes took place in a community-based location. Outcome measures were collected in a university laboratory. PATIENTS Ten individuals with PD were randomly...

PURPOSE Research demonstrates that people with Parkinson's disease (PD) benefit greatly from multidisciplinary medical care. Delaware does not have a Movement Disorder Center or a movement disorder specialist. To address this issue, the University of Delaware Nurse Managed Health Center (NMHC) developed a novel PD Telehealth Clinic serving individuals with PD and their caregivers throughout Del...

The partial discharge (PD) leads to catastrophic failure of the medium voltage (MV) switchgear insulation. Determination PD source (defect) location in high (HV) equipment is very important maintenance procedures and isolating root cause generation. In this paper, transient earth (TEV) detection method was used acquire defect-initiated signals a simulated MV model. An array four TEV sensors wer...

BACKGROUND Successful object manipulation relies on the ability to form and retrieve sensorimotor memories of digit forces and positions used in previous object lifts. Past studies of patients affected by Parkinson's disease (PD) have revealed that the basal ganglia play a crucial role in the acquisition and/or retrieval of sensorimotor memories for grasp control. Whereas it is known that PD im...

Patients with Parkinson׳s disease (PD) respond more readily than healthy controls to irrelevant stimuli that contain task-relevant, response-priming features. This behavior may reflect oversensitivity to response-relevant features of irrelevant stimuli or failure to select relevant stimuli. To decide between these alternatives, we investigated in a "contingent-capture" paradigm whether PD patie...

Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of autosomal recessive familial Parkinson's disease (PD). Efforts in deducing the PINK1 signaling pathway have been hindered by controversy around its subcellular and submitochondrial localization and the authenticity of its reported substrates. We show here that this mitochondrial protein exhibits a topology in which the kinase do...

BACKGROUND AND OBJECTIVES The purposes of this study are 1) to investigate the relationship between resting baseline Pd/Pa, determined by the ratio of the pressures proximal (Pa) and distal (Pd) to the target lesion before, inducing hyperemia and fractional flow reserve (FFR) and 2) to identify a resting baseline Pd/Pa range that might reliably preclude the need for hyperemic induction. SUBJE...

Aim The ecosystem functions and services of coral reefs are critical for coastal communities worldwide. Due to conservation resource limitation, species need be prioritized protect desirable properties biodiversity, such as functional diversity (FD), which has been associated with greater functioning but is difficult quantify directly. Selecting maximize phylogenetic (PD) shown indirectly captu...