BACKGROUND Long-term patency of conventional synthetic grafts is unsatisfactory below a 6-mm internal diameter. Poly(epsilon-caprolactone) (PCL) is a promising biodegradable polymer with a longer degradation time. We aimed to evaluate in vivo healing and degradation characteristics of small-diameter vascular grafts made of PCL nanofibers compared with expanded polytetrafluoroethylene (ePTFE) gr...

Biocompatible nanofibers that are capable of adapting to the physiological conditions of the human body have become increasingly important for clinical applications in recent years. Electrospun fiber mats offer particular advantages due to their large surface area and their sorption/release properties. If loaded with drugs, delivery properties can be tailored to a specific release rate. This re...

The aim of this study was to prepare non-woven materials from a biodegradable polymer, poly(epsilon-caprolactone) (PCL) by electrospinning. PCL was synthesized by ring-opening polymerization of epsilon-caprolactone in bulk using stannous octoate as the catalyst under nitrogen atmosphere. PCL was then processed into non-woven matrices composed of nanofibers by electrospinning of the polymer from...

To examine the influence of substrate topology on the behavior of fibroblasts, tissue engineering scaffolds were electrospun from polycaprolactone (PCL) and a blend of PCL and gelatin (PCL+Gel) to produce matrices with both random and aligned nanofibrous orientations. The addition of gelatin to the scaffold was shown to increase the hydrophilicity of the PCL matrix and to increase the prolifera...

Introduction: Drugs and biocompatible nanoparticles have raised significant potential in advancing the bone regeneration. Electrospinning technology enables full realization of value drugs nanoparticles. Methods: In this study, we successfully fabricated core–sheath nanofibers solely composed polycaprolactone (PCL) polymer. Simvastatin (SIM) was confined to core while nanohydroxyapatite (nHA) l...

BACKGROUND Development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. Gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. METHODS PLLA/PCL aligned fibrous scaffold was fabricated using electrospinning method. ADSCs...

The development of a new family of implantable bioinspired materials is a focal point of bone tissue engineering. Implant surfaces that better mimic the natural bone extracellular matrix, a naturally nano-composite tissue, can stimulate stem cell differentiation towards osteogenic lineages in the absence of specific chemical treatments. Herein we describe a bioactive composite nanofibrous scaff...

Nanofibers or microfibers produced by either of the techniques are used in tissue restoration, compact organs, construction of biocompatible prostheses, cosmetics, face masks, bone substitutes, artificial blood vessels, and valves; and drug delivery applications [3]. Scaffold materials produced from nanofibers offer a very large surface area that supports cell growth [2]. Polymers such as Polyg...

DEVELOPMENT AND APPLICATION OF BIOMIMETIC ELECTROSPUN NANOFIBERS INTOTAL JOINT REPLACEMENTbyWEI SONGMay 2014Advisor: Dr. Weiping RenMajor: Biomedical EngineeringDegree: Doctor of Philosophy Failure of osseointegration (direct anchorage of an implant by bone formation at the bone‐implant surface) and implant infection (such as that caused by Staphylococcus aur...