A model for spontaneous tumour formation in the rat pancreas is described that requires neither cocarcinogens nor dietary manipulation. Short term hypercholecystokininaemia, when induced by raw soya flour feeding, induces benign and malignant tumours of the rat pancreas. Pancreaticobiliary diversion (PBD) results in hypercholecystokininaemia and in the short term, pancreatic hyperplasia. Longte...

Objective To compare Roux-en-Y hepatico-jejunostomy with complete resection of the cyst or incomplete resection with 1-cm remnant proximal cyst wall in treating adult type I choledochal cyst (CC). Methods The medical records of 267 adult patients with type I CC from January 1998 to December 2015 were reviewed retrospectively. Among them, 171 underwent Roux-en-Y hepatico-jejunostomy with compl...

Programming by Demonstration, or PBD, is an exciting and developing branch of HCI research. With PBD techniques, end-users can add functionality to their environments without programming in the conventional sense. Virtually all research into PBD, however, presumes that the event history is a linear sequence of user actions. This paper challenges that notion by introducing Hierarchical Event His...

M. H. Skolnick et at. (1) obtained specimens by multiple fine-needle aspiration from the breasts of women with and without a family history of breast cancer. They assessed the prevalence of certain cytologic changes in these groups of women, which they labeled proliferative breast disease (PBD). Skolnick et al.'s use of this term is unfortunate because PBD is a well-recognized histologic diagno...

Scene-level Programming by Demonstration (PbD) is faced with an important challenge perceptual uncertainty. Addressing this problem, we present a scenelevel PbD paradigm that programs robots to perform goal-directed manipulation in unstructured environments with grounded perception. Scene estimation is enabled by our discriminatively-informed generative scene estimation method (DIGEST). Given s...

The effect of gastric fundectomy with hypergastrinaemia on the pancreas in rats was studied for 14 months. Rats with hypercholecystokininaemia that had had a pancreaticobiliary diversion (PBD) operation and sham operated rats served as controls. Fundectomised rats showed a significant increase in pancreatic weight and total DNA and protein content compared with sham operated rats. DNA flow cyto...

There has been a recent increase in recognition and diagnosis of pediatric bipolar disorder (PBD), along with an increase in prescriptions for psychotropic medications for treating children suffering from this chronic, potentially disabling disorder. Lithium remains the only FDA-approved mood stabilizer for use in children > 12 years of age and along with valproic acid and carbamazepine, forms ...

OBJECTIVE To examine the treatment impact of lamotrigine on the neurocognitive profile of patients with pediatric bipolar disorder (PBD). METHOD Healthy controls (HC) (n = 24; mean age = 12.4 +/- 3.3 years) and unmedicated PBD patients with manic, mixed, or hypomanic episodes (n = 34; mean age = 13 +/- 3.1 years) were matched for IQ, age, sex, race, and socioeconomic status. A neurocognitive ...

We give an algorithm for properly learning Poisson binomial distributions. A Poisson binomial distribution (PBD) of order n ∈ Z+ is the discrete probability distribution of the sum of n mutually independent Bernoulli random variables. Given Õ(1/ǫ) samples from an unknown PBD P, our algorithm runs in time (1/ǫ) , and outputs a hypothesis PBD that is ǫ-close to P in total variation distance. The ...

Polo-like kinases (PLKs) are evolutionarily conserved kinases essential for cell cycle regulation. These kinases are characterized by the presence of a C-terminal phosphopeptide-interaction domain, the polo-box domain (PBD). How the functional domains of PLKs work together to promote cell division is not understood. To address this, we performed a genetic screen to identify mutations that indep...