Prognostic genes are key molecules informative for cancer prognosis and treatment. Previous studies have focused on the properties of individual prognostic genes, but have lacked a global view of their system-level properties. Here we examined their properties in gene co-expression networks for four cancer types using data from 'The Cancer Genome Atlas'. We found that prognostic mRNA genes tend...

Description PathNet uses topological information present in pathways and differential expression levels of genes (obtained from microarray experiment) to identify pathways that are 1) significantly enriched and 2) associated with each other in the context of differential expression. The algorithm is described in: PathNet: A tool for pathway analysis using topological information.

BACKGROUND Lipid accretion is one of the major side effects of clozapine pharmacotherapy of schizophrenia that made clozapine into an interesting obesity drug model. METHOD Ingenuity Pathway Analysis (IPA) engine was used for core analysis and building the networks of weight regulation. RESULTS The examination of molecules that were selected into 'clozapine neighborhood' identified them as ...

background: the wnt/β- the wnt/β-catenin signaling pathway is involved in many developmental processes in both fetal and adult life; its abnormalities can lead to disorders including several types of cancers and malfunction of specific cells and tissues in both animals and humans. its role in reproductive processes has been proven. objective: this study was designed to evaluate the expression o...

MOTIVATION Prior biological knowledge greatly facilitates the meaningful interpretation of gene-expression data. Causal networks constructed from individual relationships curated from the literature are particularly suited for this task, since they create mechanistic hypotheses that explain the expression changes observed in datasets. RESULTS We present and discuss a suite of algorithms and t...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

accessory pathways (ap) are abnormal myocardial connections between atria and ventricles with electrical conductive properties. we performed radio frequency (rf) catheter ablation in 66 patients with manifest ap at dr.shariati hospital during 5 years. bipolar mapping was used in 48 patients and unipolar mapping in 18 patients of find the best site for rf energy delivery. we calculated total dur...

abstract: fifteen non-aflatoxigenic strains of aspergillus flavus, represent a wide range of geographic regions of iran (six provinces include fars, ardebil, guilan, golestan, kerman and semnan) and vegetative compatibility groups (vcgs), were collected from corn (zea mays l.), peanut (arachis hypogaea l.) and pistachio (pistachia vera l.) soils and kernels, were screened for the presence of af...