نتایج جستجو برای: pathologic response

تعداد نتایج: 1017639  

Journal: :Clinical advances in hematology & oncology : H&O 2016
Bingnan Zhang Sara Hurvitz

Long-term outcomes for women with a diagnosis of human epidermal growth factor receptor 2 (HER2)-driven early-stage breast cancer have significantly improved since the advent of HER2-targeted therapy. Although the first studies in the early-stage setting focused on the adjuvant use of trastuzumab plus chemotherapy, clinical trials increasingly are using a neoadjuvant design to evaluate novel HE...

2017
Morgan Steele Ioannis A Voutsadakis

AIM To investigate if pre-treatment platelet counts could provide prognostic information in patients with rectal adenocarcinoma that received neo-adjuvant treatment. METHODS Platelet number on diagnosis of stage II and III rectal cancer was evaluated in 51 patients receiving neo-adjuvant treatment and for whom there were complete follow-up data on progression and survival, as well as patholog...

Journal: :Melanoma research 2016
Sarah Sloot Jonathan S Zager Ragini R Kudchadkar Jane L Messina Jacob J Benedict Ricardo J Gonzalez Ronald DeConti Leslie M Turner Timothy McCardle Keiran S M Smalley Jeffrey S Weber Vernon K Sondak Geoffrey T Gibney

Selective BRAF inhibitors (BRAFi) yield objective responses in 50% of patients with metastatic BRAF V600E mutant melanoma. Adding an MEK inhibitor increases this response rate to 70%. Limited data are available on the outcomes of unresectable stage III patients, and it remains unclear whether BRAF-targeted therapy can be utilized as a neoadjuvant strategy. Data on patients with advanced locoreg...

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