This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator p...

We developed a new passive-type micromixer based on the baker's transformation and realized a fast mixing of a protein solution, which has lower diffusion constant. The baker's transformation is an ideal mixing method, but there is no report on the microfluidic baker's transformation (MBT), since it is required to fabricate the complicated three-dimensional (3D) structure to realize the MBT dev...

In this study, the pre-steady state development of enzymatic bioreactions using a microfluidic mixer is presented. To follow such reactions fast mixing of reagents (enzyme and substrate) is crucial. By using a highly efficient passive micromixer based on multilaminar flow, mixing times in the low millisecond range are reached. Four lamination layers in a shallow channel reduce the diffusion len...

In microfluidics mixing of different fluids is a highly non-trivial task due to the absence of turbulence. The dominant process allowing mixing at low Reynolds number is therefore diffusion, thus rendering mixing in plain channels very inefficient. Recently, passive chaotic micromixers such as the staggered herringbone mixer were developed, allowing efficient mixing of fluids by repeated stretc...

We report the development of a micromachined magnetic-bar micromixer for microscale fluid mixing in biological laboratory-on-a-chip applications. The mixer design is inspired by large scale magnetic bar mixers. A rotating magnetic field causes a single magnetic bar or an array of them to rotate rapidly within a fluid environment. A fabrication process of the magnetic bar mixer is developed. Res...

Magnetohydrodynamic mixing of two fluids in an annular microchannel is modelled as a twodimensional, laminar, convection-diffusion problem, and examined using asymptotic analysis and numerical simulation. The time T required for mixing of a plug of solute depends on the Peclét number Pe, and on the geometry of the annulus. Three scaling regimes are identified: purely diffusive, Taylordispersive...

In this paper we demonstrate, using a fabrication technique, liquid-phase photopolymerization (LP3) for the relatively fast and low-cost integration of thick polymers and electroformed metal microstructures to develop a range of microfluidic components and systems. Liquid-phase UV-photosensitive polymers, similar to negative-tone photoresists, are used to create both polymer microstructures and...