OBJECTIVE To evaluate the effectiveness of a home-based cognitive rehabilitation (CR) program based on the video game Dr Kawashima's Brain Training (DKBT; Nintendo, Japan), in improving attention, processing speed, and working memory of patients with multiple sclerosis (MS). METHODS This was a randomized, wait-list control study. Patients with MS and failure in at least one between Stroop Tes...

Objective: When Sativex  THC:CBD cannabinoid-based oromucosal spray was first approved as a prescription medicine for multiple sclerosis (MS) spasticity, there was some concern about its possible long-term impact on cognition and mood. The objective of this study was therefore to assess the long-term impact of Sativex on cognitive function and mood in MS patients with spasticity. Methods: 121 ...

ETNIER, J. L., R. J. CASELLI, E. M. REIMAN, G. E. ALEXANDER, B. A. SIBLEY, D. TESSIER, and E. C. MCLEMORE. Cognitive Performance in Older Women Relative to ApoE-?4 Genotype and Aerobic Fitness. Med. Sci. Sports Exerc., Vol. 39, No. 1, pp. 199–207, 2007. Introduction: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, the...

BACKGROUND AND PURPOSE Abnormalities in GABA concentration [GABA] have been associated with several neuropsychiatric disorders, and research has suggested that GABA may play a role in sensorimotor cortex function. We sought to determine whether identifying a change in [GABA] within the sensorimotor cortex of patients with MS has any effect on motor function and would provide information about t...

This study compared 19 older adults and 20 younger adults on the Groton Maze Learning Test((c)) (GMLT), a novel computerized hidden maze learning test that assesses processing speed, spatial learning efficiency, and error monitoring. Convergent validity of this test was assessed by comparing GMLT scores to Paced Auditory Serial Addition Test (PASAT) and Tower of Toronto (TOT) scores. In the ful...

INTRODUCTION The paced serial addition test (PSAT) is regularly used to assess cognitive deficits in various neuropsychiatric conditions. Being a complex test, it reflects the status of multiple cognitive domains such as working memory, information processing speed and executive functioning. Two versions of the PSAT exist. One uses auditory stimuli through spoken numbers and is known as the PAS...

INTRODUCTION In this article, we report the data regarding treatment adherence of a group of patients with multiple sclerosis (MS) and relapsing-remitting or secondary progressive disease who were followed in the MS outpatient clinic of Bozyaka Education and Research Hospital, Izmir. METHODS We collected the demographic data of 219 patients with MS who were treated with immunomodulatory drugs...

OBJECTIVE To compare the cognitive performance of subjects with chronic fatigue syndrome (CFS), multiple sclerosis (MS), and healthy controls. All subjects were matched for age, education, and verbal intelligence, as previous neuropsychological studies of CFS had not used appropriate control groups. DESIGN Case-control design. All subjects were given a neuropsychological battery and the test ...