paper presents the work carried out in developing a precision, bolus injection system to study the effect of regional deposition of fine particulate matter (PM) within the human respiratory system and to investigate the optimal conditions for inhaled drug delivery. In contrast to existing methods, the new system computes parameters necessary and injects PM into breath cycles by a process of dyn...

The delivery of therapeutic proteins has gained momentum with development of biotechnology. However, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (GIT) resulted in low absorption. The main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhGH) on the basis of parti...

Abstract Solid lipid nanoparticles (SLNs), the spheroidal-shaped, colloids state lipophilic-natured, innovative nanoscale particulate materials, are being concurrently prepared by quality-by-design approach for cellular and sub-cellular delivery of drugs other payloads with facilitated physicochemical characteristics targeted delivery. The drugs, pharmaceuticals biopharmaceutical genes to disea...

Development of delivery systems for new drug for its safe and effective delivery it into the body is an integral part of drug research program. This is particularly true due to increased incidence of adverse pharmacokinetic behavior of new drugs developed recently. Alternative delivery systems have been researched extensively not only to modulate their kinetic behavior in the body but also to a...

Diseases or disorders affecting the posterior segment of the eye, such as diabetic retinopathy, age related macular degeneration and retinitis pigmentosa, are the leading causes of decreased visual acuity and blindness. Successful treatment modalities require generation and maintenance of therapeutically effective drug concentrations at the target sites: vitreous, retina and/or choroid. Drug de...

The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local drug delivery, due to the lung's favourable properties of a large surface area and high permeability. Pulmonary drug delivery possesses many advantages, including non-invasive route of administration, low metabolic activity, control environment for systemic absorption and avoids first bypass metabolism. H...