Gestational trophoblastic neoplasia (GTN) includes the abnormal pregnancies complete (CHM) and partial hydatidiform mole (PHM) and the malignant gestational trophoblastic tumours (GTT) invasive mole (IM), choriocarcinoma, placental site trophoblastic tumour (PSTT) and epithelioid trophoblastic tumour (ETT). While many genetic studies have been performed in both CHM and PHM, similar studies of t...

Coexistence of a viable foetus with a complete hydatidiform mole is a rare entity. Traditionally, termination of pregnancy was recommended because of severe maternal and foetal complications. Here we report a case of a 30 year old G2A1 at 27 weeks with a twin pregnancy with a complete hydatidiform mole and coexisting normal foetus who took home a healthy baby without any persistent trophoblasti...

BACKGROUND Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumour. The incidence of GTD varies in different parts of the world. The malignant potential of this disease is higher in South East Asia in comparison to western countries. Objectives of stu...

BACKGROUND Hydatidiform moles carry a significant risk for developing persistent gestational trophoblastic disease. Lectins are useful tools to identify cellular glycosylation pattern and changes in glycosylation that occur during growth, development, differentiation and also, during disease states. OBJECTIVES Considering the changes in glycosylation that occur during cell proliferation, diff...

Chemotherapy, in conjunction with other methods of treatment, was used in 100 patients with invasive hydatidiform mole or choriocarcinoma following mole. When treatment was instituted within two to six months of the antecedent mole serious drug resistance was not encountered, drug toxicity was slight, the duration of treatment was comparatively short, and sustained remissions were obtained in 5...

UNLABELLED The persistence of polymorphic trophoblastic hyperplasia in a hydatidiform mole is an extremely rare condition. Its early diagnosis is essential since such cases can transform into invasive tumours. MATERIALS AND METHODS The paraffin-embedded biopsies were routinely stained with HE. Immunohistochemical staining reactions were performed with monoclonal antibodies against inhibin-alp...

Background: The pathomechanisms of gestational trophoblastic disease have not yet been able to be extensively understood. It is associated with oxidative damage related to the production of reactive oxygen species (ROS). Estrogen, as well as all of its metabolites, can produce ROS. Therefore it is necessary to analyze how far the involvement of estrogen, in this case 17β estradiol, to the patho...

Hydatidiform mole (often referred to as molar pregnancy) is the most common disorder in a category of pathologies known as Gestational Trophoblastic Diseases that are associated with abnormal fertilization in pregnancy. Current practices in screening and monitoring during early pregnancy allow for better identification of hydatidiform mole, sometimes prior to the onset of significant symptoms.O...

a twin pregnancy with a coexisting complete hydatidiform mole and a healthy fetus (cmcf) is rare. here we report three cases of cmcf with different clinical courses but similar outcome without a surviving neonate. two women required uterine evacuation before 20 weeks of gestational age because of vaginal bleeding and medical complications and the other patient underwent termination of her pregn...