New products may be sought by modifying older fermentation products, exemplified by the semisynthetic antibiotic tilmicosin and other derivatives of tylosin. Another approach is to screen fermentation broths, exemplified by the discovery of the structurally-unique insecticidal macrolide spinosad. The polyketide class of fermentation products encompasses a wide diversity of chemical structures a...

We study optimization methods for source-initiated energy-efficient broadcast in all-wireless networks. Past studies on energy-efficient broadcast [1,3,5] focus on deterministic optimization to construct an energy-efficient broadcast tree. We present a Random Tree Optimization (RTO) approach that transforms the deterministic optimization problem into a related stochastic one. We apply the cross...

The generation o f accelerators currently under construction promises to enable physicists to probe various extensions o f the Standard Model (SM), including Supersymmetric and Left -Right Symmetric models. Each of these models introduces new groups o f presently-undetected particles, whose experimental signals must be distinguished from known SM processes. In the cases o f charged Higgs bosons...

O n his way to neurology grand rounds, Robert (Bob) Joynt, MD, PhD, died suddenly on April 13, 2012, at the age of 86 years in Rochester, New York. He is survived by his wife, Margaret; their 6 children Robert, Patricia, Mary, Anne, Thomas, and Kathleen and their spouses; and 9 grandchildren. Joynt was chief editor of the Archives of Neurology (1982-1997); a trifecta president of the American A...

Electronic commerce is exploding Forrester research projects 25 billion dollars in online spending by the year 2000. As the market segment grows, it has expanded into broader content areas. Broader domains increase the need for thoughtful content organization and browsing support. We promote the trend of using ontologies to support more than just search and also to to enhance browsing and more ...

A primary interest of the field of infant mental health is in the early conditions that place infants at risk for less than optimal development. The fundamental problem of what constitutes normal and abnormal development is now a focus of developmental psychology, infant psychiatry, and developmental neuroscience. In the second part of this sequential work, I present interdisciplinary data to m...