Thyroid cancer is the most common endocrine malignant disease and the incidence is increasing. DACT2 was found frequently methylated in human lung cancer and hepatocellular carcinoma. To explore the epigenetic change and the role of DACT2 in thyroid cancer, 7 thyroid cancer cell lines, 10 cases of non-cancerous thyroid tissue samples and 99 cases of primary thyroid cancer samples were involved ...

OBJECTIVE The objective was to evaluate the clinical behavior and outcome of 202 papillary thyroid cancers in Graves' disease patients during the period 1994-2004. DESIGN This was a retrospective, non-randomized case-control study. METHODS Since 1994, we have included an ultrasonogram of the neck in the initial examination of thyroid disease patients who consult our outpatient clinic. We ev...

Well-differentiated papillary and follicular thyroid carcinomas are the two most common types of thyroid cancer. Although cancerous cells in both types phenotypically resemble the epithelial follicular cell, the tumors display different histological characteristics and clinical outcomes. Molecular defects contributing to the separate development pathways remain largely unclear. We evaluated gen...

Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated in tumor progression and metastasis. However, its functional significance and underlying molecular mechanisms in thyroid cancer remain to be elucidated. In the present study, we detected the potential function of AEG-1 in papillary thyroid cancer (PTC). We also investigated the relation b...

Aim of this study was to determine whether there are any differences between coastal and inland Dalmatia in incidence rates and clinical characteristics of thyroid cancer. Data on 651 persons who suffer from and have undergone surgery for thyroid cancer have been analysed. All patients lived in Dalmatia between 1997 and 2006. Data were collected via surveys, insight into medical histories and r...

thyroid hemiagenesis can be associated with various thyroid pathologies such as papillary thyroid cancer or nodular goiter. however, we did not encounter any publication in the literature in which hemiagenesis could be observed together with retrosternal goiter. in this report, a thyroid hemiagenesis associated with a benign nodular goiter extending retrosternally is reported. a 59-year-old mal...

Tumor stroma-secreted growth factors, cytokines, and reactive oxygen species (ROS) influence tumor development from early stages to the metastasis phase. Previous studies have demonstrated downregulation of ROS-producing extracellular superoxide dismutase (SOD3) in thyroid cancer cell lines although according to recent data, the expression of SOD3 at physiological levels stimulates normal and c...

The thyroid gland is the largest endocrine in body. Among functions of this gland, we can mention secretion hormones thyroxine (T4) and triiodothyronine (T3), whose release occurs by control stimulating hormone (TSH). Furthermore, it involved calcium metabolism, through calcitonin. Thyroid cancer rare (about 1% all neoplasms), however most frequent among malignant neoplasms. Papillary carcinoma...

Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified. Therefore, we decided to examine the expression of both FGFR-2 isoform, FGFR-2-IIIb and FGFR-2-IIIc, in different histological thyroid variants such as hyperplasia, follicular adenoma and...

3-4 October 2014 Naples, Italy Multi disciplinary Conference on Hepatocellular Carcinoma Museo Diocesano www.epatocarcinomacampania.com Background Thyroid cancer represents the most common cancer of the endocrine system. In 2014, 62,980 new cases and 1,890 deaths are estimated to occur in the United Sates. Thyroid cancer occurs more frequently in women than in men, and represents 5% of estimate...