Over the past 60 years, the mortality from cervical cancer — once one of the most common and lethal cancers in women in the United States — has decreased dramatically. Much of the reduction has been due to the widespread use of the Papanicolaou test, which has enabled clinicians to detect cervical intraepithelial neoplasia before it progresses to cervical cancer and to detect cervical cancer at...

Background: Numerous studies indicate that Papanicolaou smears contain better cellular material when the technique for collecting the sample employs the Zelsmyn Cytobrush TIl. Few studies, however, have examined its ability to increase the percentage of abnormal Papanicolaou smear results in actual clinical practice. Methods: This study looked at 7999 Papanicolaou smears done by 46 primary care...

Evidence for the clinical utility of human papillomavirus (HPV) DNA testing has increased over the years and has now become very convincing. Some specific uses of HPV detection are a) triage of women with cytological determinations of atypical squamous cells of undetermined significance (ASC-US) and related management strategies, b) as a marker for test of cure post-treatment, and c) most impor...

BACKGROUND The purpose of this study was to compare the efficacy of 0.75% metronidazole vaginal gel with no treatment in patients who have had a minimally abnormal Papanicolaou smear. METHODS One hundred forty-five patients whose initial Papanicolaou smears were limited by inflammation or benign cellular changes, reactive cellular changes, or atypical squamous cells of undetermined significan...

Background: Different histochemical stains have been applied to demonstrate the cytotoxic and genotoxic effects of cigarette smoking on cells. Feulgen Papanicolaou were most popular nuclear abnormalities. The aim this study was compare in demonstrating exfoliated oral mucosa Methods: A total 31 smokers 15 non-smokers included case-control study. Using a wooden spatula, two samples taken from ea...