نتایج جستجو برای: pancreatic islet

تعداد نتایج: 94599  

Journal: :Diabetology and Metabolic Syndrome 2009
Maria Lúcia Corrêa-Giannella Alexandre S Raposo do Amaral

BACKGROUND No formulation of exogenous insulin available to date has yet been able to mimic the physiological nictemeral rhythms of this hormone, and despite all engineering advancements, the theoretical proposal of developing a mechanical replacement for pancreatic beta cell still has not been reached. Thus, the replacement of beta cells through pancreas and pancreatic islet transplantation ar...

2015
E. Ilegems P. P. van Krieken P. K. Edlund A. Dicker T. Alanentalo M. Eriksson S. Mandic U. Ahlgren P.-O. Berggren

The pancreatic islet of Langerhans is composed of endocrine cells producing and releasing hormones from secretory granules in response to various stimuli for maintenance of blood glucose homeostasis. In order to adapt to a variation in functional demands, these islets are capable of modulating their hormone secretion by increasing the number of endocrine cells as well as the functional response...

2017
Dan Wang Xiaoming Ding Wujun Xue Jin Zheng Xiaohui Tian Yang Li Xiaohong Wang Huanjin Song Hua Liu Xiaohui Luo

It is unknown whether a scaffold containing both small intestinal submucosa (SIS) and mesenchymal stem cells (MSCs) for transplantation may improve pancreatic islet function and survival. In this study, we examined the effects of a SIS-MSC scaffold on islet function and survival in vitro and in vivo. MSCs and pancreatic islets were isolated from Sprague-Dawley rats, and SIS was isolated from Ba...

2018
Danielle J. Borg Felicia Y. T. Yap Sahar Keshvari David G. Simmons Linda A. Gallo Amelia K. Fotheringham Aowen Zhuang Robyn M. Slattery Sumaira Z. Hasnain Melinda T. Coughlan Phillip Kantharidis Josephine M. Forbes

The contribution of environmental factors to pancreatic islet damage in type 1 diabetes remains poorly understood. In this study, we crossed mice susceptible to type 1 diabetes, where parental male (CD8+ T cells specific for IGRP206-214; NOD8.3) and female (NOD/ShiLt) mice were randomized to a diet either low or high in AGE content and maintained on this diet throughout pregnancy and lactation....

Journal: :Journal of cell science 1994
V Cirulli D Baetens U Rutishauser P A Halban L Orci D G Rouiller

Endocrine cell types are non-randomly distributed within pancreatic islets of Langerhans. In the rat, insulin-secreting B-cells occupy the core of the islets and are surrounded by A-, D- and PP-cells, secreting glucagon, somatostatin and pancreatic polypeptide, respectively. Furthermore, dissociated islet cells have the ability in vitro to form aggregates with the same cell-type organization as...

Journal: :Diabetes 1985
S Srikanta A Rabizadeh M A Omar G S Eisenbarth

Assays for islet cell antibodies (ICA) are finding increasing application in clinical diabetology. We have developed a new islet cell antibody assay system (ICA-pA), whose salient features include: (1) utilization of fluorescein-conjugated staphylococcal protein A as a standard second-step reagent, the advantages of this approach being improved "signal" (islet)/"noise" (acini) ratio due to redu...

Journal: :Clinical science 2012
Lin Wu Anna Olverling Zhen Huang Leif Jansson Hongfen Chao Xin Gao Åke Sjöholm

GLP-1 (glucagon-like peptide 1) and its mimetic exendin-4 are used against Type 2 diabetes. C-peptide has also proven promising to enhance insulin action. Since insulin secretion in vivo can be rapidly tuned by changes in islet microcirculation, we evaluated the influence of GLP-1, exendin-4 and C-peptide on pancreatic IBF (islet blood flow), and dynamic changes in insulin secretion and glycaem...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015
Jeffrey R Vercollone Maarten Balzar Sergey V Litvinov Wendy Yang Vincenzo Cirulli

Our previous work demonstrated an important role of EpCAM in the regulation of pancreatic cell adhesion, growth and differentiation. Here we investigated the consequences of human EpCAM (hEpCAM) overexpression under the control of the MMTV-LTR promoter, known to drive robust gene expression in a number of ductal epithelia, including the pancreas. In this animal model (MMTV-hEpCAM) we uncovered ...

Journal: :Endocrine journal 2007
Hirofumi Noguchi

Pancreatic islet transplantation has been remarkably improved by the Edmonton protocol; however, it is not easy to achieve insulin independence after islet transplantation from one donor pancreas. The islet isolation procedure itself destroys cellular and noncellular components of the pancreas that probably play a role in supporting islet survival. Further islet transplantation exposes cells to...

Journal: :Transplantation proceedings 1992
W J Tze J Tai S S Cheung C Ricordi N Murase T E Starzl

TRANSPLANTED pancreatic islet tissue has been shown to restore normoglycemia and prevent the development of chronic complications in diabetic animals. 1 The application of alloand xenotransplantation of pancreatic islets for the treatment of diabetes is hindered by immune rejection. FK 506, a new immunosuppressive agent, has been demonstrated to be effective in the prolongation of survival of h...

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