A double-duct sign is the combined dilatation of the common bile duct and pancreatic duct, often caused by cancer of the pancreas. We present a patient with colicky pain in the right upper quadrant of her abdomen. On radiological imaging and endosonography, she had a double-duct sign due to choledocholithiasis and no mass in the pancreatic head. A literature search was performed, which indicate...

Carbohydrate antigens are useful markers for the serological detection of pancreatic cancer. However, data concerning the expression of structurally well-defined carbohydrate antigens in normal and malignant pancreatic tissue is quite limited. The Lex and Leg antigens are closely related carbohydrate antigens synthesized on type 2 blood group oligosaccharide side chains of glycolipids and glyco...

A 66-year-old man was referred to our hospital due to carbohydrate antigen 19-9 (CA19-9) elevation. Further examination revealed no obvious malignancy, but abdominal enhanced computed tomography (CT) showed soft tissue density around the celiac axis and superior mesenteric artery (SMA). Although pancreatic cancer was considered as a possible diagnosis, there was no clear evidence within the pan...

Introduction Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various bi...

Timothy I. Carter, MD, Charles J. Yeo, MD, Harish Lavu, MD* Department of Surgery, SUNY Downstate Medical Center, 450 Clarkson Avenue Brooklyn, New York, NY 11203, USA; Department of Surgery, The Jefferson Pancreas Biliary and Related Cancer Center, Thomas Jefferson University, 1015 Walnut Street, Curtis Building, Suite 620, Philadelphia, PA 19107, USA; Department of Surgery, The Jefferson Panc...

there had been few if any study for second pancreas transplant outcome and consequences in patients with simultaneous kidney pancreas transplant after failure of the first pancreas allograft. the aim of this study was to compare the patient and graft survival and clinical outcomes and complication of the second pancreas transplant in patients with simultaneous kidney pancreas, compared with pan...

In order to compare the survival rate in Japan with those in the USA and European countries, we abstracted the 5-year relative survival rate from several data sources. Survival rates of cancer diagnosed in 1995–99 in the USAwere abstracted from 18 cancer registries in the Surveillance Epidemiology and End Results (SEER) data (1). Survival rates of cancer diagnosed in 1995–99 in the UK and Norwa...

CONTEXT Primary lung cancer frequently metastasizes to distant organs; however, the pancreas is a relatively infrequent site of metastasis. Because most metastatic cases in the pancreas tend to be discovered in patients only after malignant disease has become widely disseminated, it is extremely rare that a metachronous metastatic lesion limited to the pancreas is discovered with postoperative ...

Introduction Raman spectroscopy is a vibrational spectroscopic technique, based on inelastic scattering of monochromatic light. This technique can provide valuable information about biomolecular changes, associated with neoplastic transformation. The purpose of this study was to find Raman spectral markers for distinguishing normal samples from cancerous ones in different tissues. Materials and...