BACKGROUND The anticancer properties of cisplatin and palladium(II) complexes stem from the ability of the cis-MCl2 fragment to bind to DNA bases. However, cisplatin also interacts with non-cancer cells, mainly through bonding molecules containing -SH groups, resulting in nephrotoxicity. This has aroused interest in the design of palladium(II) complexes of improved activity and lower toxicity. ...

Roslin, S. 2017. Exploring Palladium-Mediated C/C-Carbonylation Reactions. PET Tracer Development Targeting the Vesicular Acetylcholine Transporter. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 241. 99 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0136-5. The work presented herein describes the utilization and exploration of palladium-medi...

Neutral chloromethylpalladium(II) complexes, [Pd(Cl)(CH3)(L)] (1a-5a) with ligands κ(2)-N^S-2-((3,5-di-tert-butyl-1H-pyrazol-1-yl)methyl)-6-(phenylthiomethyl)pyridine (L1), κ(2)-N^S-2-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-6-(phenylthiomethyl)pyridine (L2), κ(2)-N^Se-2-((3,5-di-tert-butyl-1H-pyrazol-1-yl)methyl)-6-(phenylselanylmethyl)pyridine (L3), κ(2)-N^Se-2-((3,5-dimethyl-1H-pyrazol-1-yl)me...

A comparative study on the sensing properties of a tapered optical fiber pristine and functionalized with the palladium nanoparticles to hydrogen and volatile organic compounds (VOCs), is presented. The sensor response and, response/recovery times were extracted from the measurements of the transient response of the device. The tapered optical fiber sensor was fabricated using a single-mode opt...

Electrical generation from hydrogen, the element with higher energy density per unit mass, requires appropriated materials that can be used in its storage [1]. Palladium, with a high capacity to dissociate, absorb and desorb gaseous hydrogen, has been widely used for hydrogen storage [2], in separation membranes [3] and catalytic hydrogenation [4]. The present DFT calculations on clusters model...

A set of research methods (X-ray phase, desorption, kinetic) was used to determine the state basic components K2PdCl4 and Cu(NO3)2 in catalyst for oxidation carbon monoxide by oxygen. It found that palladium (II) copper initial compounds under action fiber carrier change their state. Palladium is reduced X-ray amorphous Pd0, form a crystalline phase Cu2(OH)3Cl. exhibits protective properties wi...

The syntheses of nickel(II)porphyrins bearing palladium(II) or platinum(II) complexes at their periphery were performed. These new compounds characterized by standard spectroscopic techniques and studied electrochemistry. electrochemical data then compared with previously published porphyrin dimers linked metal ions like platinum(II). An X-ray structure one these species was obtained confirmed ...

Selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1H)On e (2) to 3,5-dimethyl-7H-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . For elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). These compounds underwent isomerization to (3) and (4...

Decarbonylation of carboxylic acids provides an effective protocol for producing alpha olefins; however, previous literature has focused on the palladium-bisphosphine catalysts and only sporadically studied palladium-monophosphine catalyst. To investigate catalytic activity catalyst decarbonylation acids, new monophosphine ligands were synthesized (NP-1, NP-2, CP-1 CP-2). By employing (1–3 mol%...