CLINICAL SIGNS ASSOCIATED WITH BONE AND JOINT TUMORS Appendicular tumors most commonly are associated with lameness. It usually is chronic and progressive, but occasionally dogs can present acutely with severe lameness associated with pathologic fracture. A firm to hard swelling might or might not be palpable, but pain usually is elicited on palpation of the affected site of the bone. Most dogs...

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression. The receptor activator of nuclear factor-kappaB (RANK)/RANK ligand pathway has emerg...

abstract purpose: metastatic breast cancer has remained as an incurable disease. the main objectives of treatments include alleviating of symptoms, delaying disease progression and increasing survival without any adverse effect on the quality of life. the main purpose of this study was to investigate the effects of some clinocopathological factors on the survival of patients with metastatic bre...

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression. The receptor activator of nuclear factor-κB (RANK)/RANK ligand pathway has emerged a...

b-cell lymphoblastic lymphoma (b-lbl) is an uncommon subtype of pediatric non-hodgkin lymphoma (nhl) which rarely involves the skin primarily. the positron emission tomography with 2-deoxy-2-[fluorine- 18] fluoro-d: -glucose integrated with computed tomography (18f-fdg pet/ct) scan findings of a 8-year-old boy with cutaneous b-lbl were presented. pet/ct scan demonstrated mild fdg uptake in the ...

Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients with severe complications such as fracture, bone pain, and hypercalcemia. The pathogenesis of osteolytic bone metastasis depends on cross-communications between tumor cells and various stromal cells residing in the bone microenvironment. Several growth factor signaling pathways, secr...

Background: Bone-only metastatic breast cancer is believed to be non-life-threatening, and mild therapy frequently selected avoid adverse events of drug therapy. However, the prognoses such patients are not well studied. Methods: Patients who received therapies for between 2004 2016 at our institution were divided into “Bone-only metastasis”, “non-visceral”, “visceral” groups based on mode firs...

Bone metastasis is a multistep process that includes cancer cell dissemination, colonization, and metastatic growth. Furthermore, this process involves complex, reciprocal interactions between cancer cells and the bone microenvironment. Bone resorption is known to be involved in both osteolytic and osteoblastic bone metastasis. However, the precise roles of the bone resorption in the multistep ...