BACKGROUND To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. MATERIALS AND METHODS A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reactio...

INTRODUCTION In autism spectrum disorders (ASD), complex gene-environment interactions contribute to disease onset and progress. Given that gastro-intestinal dysfunctions are common in ASD, we postulated involvement of microbial dysbiosis in ASD and investigated, under a case-control design, the influence of DNA polymorphisms in the CLEC7A gene that encodes a pivotal fungal sensor, Dectin-1. ...

We aimed to evaluate the role of genetic polymorphisms in IL-1β, IL-8 and IL-10 in the risk of coronary artery disease (CAD). We identified 325 patients with CAD and 342 control subjects without CAD between January 2013 and December 2014. Genotyping of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T was performed in a 384-well plate format on the Sequenom MassARRAY ...

A geometric graph ( = gg) is a pair G = (V, E), where V is a finite set of points ( = vertices) in general position in the plane, and E is a set of open straight line segments ( = edges) whose endpoints are in V. G is a convex gg ( = egg) if V is the set of vertices of a convex polygon. For n 3 1, 0 se c (;) and m Z= 1 let 2 = Z(n ,e, m) (I, = I,(n, e, m)) be the maximal number such that for ev...

There is conflicting evidence on the contribution of the MCP-1 -2518 A>G (rs 1024611) polymorphism to SLE incidence and clinical manifestations. We examined the prevalence of the MCP-1 -2518 A>G polymorphism in SLE patients (n = 199) and controls (n = 250) in Poland. We did not observe a significant difference in the distribution of MCP-1 -2518 A>G polymorphic variants in patients with SLE and ...

OBJECTIVES Glioma is the most common central nervous system tumor. This systematic review and meta-analysis is aimed to systematically assess the association of XRCC1 polymorphisms with the risk of glioma. METHODS Such databases as EMbase, PubMed, The Cochrane Library, the China National Knowledge Infrastructure (CNKI) platforms, VIP and WanFang were searched up to April 2015 to collect case-...

BACKGROUND Lung cancer is the most common second primary cancer. We investigated whether the TNF-alpha-308 and TNF-alpha-238 polymorphisms were associated with the susceptibility and severity of lung cancer as the second primary cancer (LC2). MATERIAL/METHODS This study included 104 patients from the group LC2. The control subjects included 2 groups. The first control group (LC1) comprised 20...

Background: Gb proteins have traditionally been thought to complex with Address: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Gg proteins to function as subunits of G protein heterotrimers. The Connecticut 06520, USA. divergent Gb5 protein, however, can bind either Gg proteins or regulator of G protein signaling (RGS) proteins that contain a G gamma–like (GGL...

The nonabelian tensor square G⊗G of the group G is the group generated by the symbols g ⊗ h, where g, h ∈ G, subject to the relations gg′ ⊗ h = (gg′ ⊗ h)(g ⊗ h) and g ⊗ hh′ = (g ⊗ h)(g ⊗ hh′) for all g, g, h, h′ ∈ G, where gg′ = gg′g−1 is conjugation on the left. Following the work of C. Miller [18], R. K. Dennis in [10] introduced the nonabelian tensor square which is a specialization of the m...

The polymorphism of the vascular endothelial growth factor (VEGF) -634C/G has been correlated with susceptibility to osteonecrosis of the femoral head (ONFH). The aim of this study was to derive a more precise estimation of the relationship between the VEGF -634C/G polymorphism and ONFH by performing a meta-analysis. We searched articles indexed in Pubmed, OVID and Web of Science published up t...