Progesterone (P4) plays different physiological roles, including reproductive and non-reproductive actions. Most of P4 effects are mediated by its interaction with its nuclear receptor (PR). Among the non-reproductive functions of P4, the regulation of the immune response, particularly during pregnancy, is remarkably important. P4 is able to modulate the immune response during normal physiologi...

Because the establishment of pregnancy begins at the uterine horn ipsilateral to the corpus luteum (ipsi-horn) in cattle, levels of progesterone (P4) and receptor expression in the endometrial tissue, which regulate the intrauterine environment for embryo development, may differ between the ipsi-horn and the uterine horn contralateral to corpus luteum (contra-horn). The aim of the present study...

Longicin, a defensin-like peptide, was recently identified in the hard tick Haemaphysalis longicornis. Longicin and one of its synthetic partial analogs (P4) displayed antimicrobial/fungicidal/parasiticidal activity. In the present study, we compared longicin-derived synthetic analogs in order to characterize the antimicrobial motif (P4) by analyzing some structural features using various bioin...

Abrupt weaning, a usual management in sheep productive systems, may provoke behavioural and physiological responses indicative of stress in ewes and lambs. Progesterone (P4) has anxiolytic and sedative effects through the union of its metabolites that contain 3α-hydroxyl group to the γ-aminobutyricacidA receptor. Our first aim was to determine whether P4 administration reduces the behavioural a...

The biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. This interaction extremely affects various functions. Lower consumption of omega-3 during gestation leads to various disorders, even in hearing. We aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. In this experimental study, the auditory brainstem response...

The structural, mechanical, anisotropic, electronic and thermal properties of Si, Si0.667Ge0.333, Si0.333Ge0.667 and Ge in P4₂/ncm phase are investigated in this work. The calculations have been performed with an ultra-soft pseudopotential by using the generalized gradient approximation and local density approximation in the framework of density functional theory. The achieved results for the l...

Recent research demonstrated the utility of fecal progestagens (P4) for detecting pregnancy in elk (Cervus elaphus) during mid- to late gestation. Several factors, however, may influence fecal P4 excretion and limit its use in free-ranging animals. We investigated the effects of nutrition and body condition (percent ingesta-free body fat) on fecal P4 concentrations and incidence of abortion. Du...

The breast cancer resistance protein (BCRP) is abundant in the placenta and protects the fetus by limiting placental drug penetration. We hypothesize that pregnancy-specific hormones regulate BCRP expression. Hence, we examined the effects of progesterone (P4) and 17beta-estradiol (E2) on BCRP expression in the human placental BeWo cells. P4 and E2 significantly increased and decreased BCRP pro...

increase in feed intake of broiler breeder hens, results to incidence of metabolic and hormonal changes and finally leads to poor reproductive performance. an experiment was conducted to evaluate responses of feed-satiated and feed-restricted laying breeder hens to daily injection of an acute dose of progesterone (p4). a total of 64 cobb 500 hens were fed either restricted or ad libitum from 27...

P4 allows a new level of dynamism for routers beyond OpenFlow 1.4 by allowing headers and tables to be modified by software in the field. Without care, P4 can unleash a new wave of software bugs. Existing tools (e.g., VeriFlow, NetPlumber, Hassel, NoD) cannot model changes to forwarding behaviors without reprogramming tool internals or having users manually add new forwarding models. Further, a...