One model for the timing of cytokinesis is based on findings that p34(cdc2) can phosphorylate myosin regulatory light chain (LC20) on inhibitory sites (serines 1 and 2) in vitro (Satterwhite, L.L., M.H. Lohka, K.L. Wilson, T.Y. Scherson, L.J. Cisek, J.L. Corden, and T.D. Pollard. 1992. J. Cell Biol. 118:595-605), and this inhibition is proposed to delay cytokinesis until p34(cdc2) activity fall...

post-traumatic stress disorder (ptsd) is an increasingly recognized and theoretically preventable condition. in fact ptsd is a mental disorder that can develop after a person is exposed to a traumatic event or threats, such as war and traffic crashes. symptoms may include distressing thoughts and increased arousal. these signs last for more than one month after the event. people with ptsd are a...

p34 kinase, the product of the CDC2 gene, is a cell-cycle regulated protein kinase that is most active during mitosis. In HeLa cells, p34 kinase has previously been shown to exist in both a low- and a high-molecular-mass form, the latter of which is only found in cells in the G2/M phase of the cell cycle and contains a 62-kDa subunit. Here we show that although each form of the kinase phosphory...

Signal transduction cascades involved in regulation of the cell cycle machinery are poorly understood. In the Xenopus oocyte model, meiotic maturation is triggered by MPF, a complex of p34(cdc2)-cyclin B, which is activated in response to a progesterone signal by largely unknown mechanisms. We have previously shown that the p21-activated kinase (PAK) family negatively regulates the MPF amplific...

Ribosome biogenesis is a highly complex and conserved cellular process that is responsible for making ribosomes. During this process, there are several assembly steps that function as regulators to ensure proper ribosome formation. One of these steps is the assembly of the 5S ribonucleoprotein particle (5S RNP) in the central protuberance of the 60S ribosomal subunit. In eukaryotes, the 5S RNP ...

Punctate palmoplantar keratoderma type 1 (PPKP1, OMIM#148600), also known as the Buschke-FischerBraurer type, is a rare form of palmoplantar keratoderma that is autosomal dominantly inherited (1). PPKP1 is clinically characterised by multiple punctate hyperkeratotic papules affecting the palmar and plantar skin, with considerable phenotypic variation among patients (2). These circumscribed papu...

In this paper, we prove a supercongruence via the Wilf–Zeilberger method and symbolic summation algorithms in setting of difference rings. That is, for any prime p>3,∑n=0(p−1)/23n+1(−8)n(2nn)3≡p(−1p)+p34(2p)Ep−3(14)(modp4), where (⋅p) stands Legendre symbol, En(x) are Euler polynomials. This confirms special case recent conjecture Z.-W. Sun (Sun, 2019, (2.18)).

Post-traumatic stress disorder (PTSD) is an increasingly recognized and theoretically preventable condition. In fact PTSD is a mental disorder that can develop after a person is exposed to a traumatic event or threats, such as war and traffic crashes. Symptoms may include distressing thoughts and increased arousal. These signs last for more than one month after the event. People with PTSD are a...