new derivatives of 2-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. in pharmacological evaluatio...

adsorption of 1-butanol, phenol, and p-nitrophenol on activated carbon havebeen studied. the results were used to testifying the validity of different modelsbased on thermodynamic principles: freundlich, langmuir and henry isotherms.the maximum capacity of adsorbent for three compounds was determined, theconstants of equilibrium were determined by freundlich isotherm and virialisotherm expressi...

conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...

one-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. in this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,with optically ac...

to evaluate effected of supplemental irrigation and seed priming on yield and some quantity and quality characteristics of  vetch (vicia dasycarpa) rainfed maragheh cultivar, an experiment was carried out at the research farm of faculty agriculture of urmia university, west azarbaijan province, iran, during 2011. the experimental design was split-plot, laid out in randomized complete block with...

considering that the effective yield of a panel is equal to its total number of hours of solar radiation and temperature, only the effects of temperature and solar radiation intensity at the maximum power point (mpp) are investigated in this article. by collecting temperature data, sun's radiation hours from six synoptic meteorological stations in kermanshah province over the course of an ...

a two-dimensional nanolayered polyoxomolybdate, [4,4´-h2bipy] [mo7o22].h2o (1), where 4,4´-bipy = 4,4´-bipyridine, was prepared and characterized by ft-ir and atomic absorption spectroscopies, transmission electron microscopy (tem), x-ray single crystal and powder diffraction (xrd), and thermogravimetric analysis. the catalytic performance of 1 was assessed in the epoxidation of some olefins em...

1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. these compounds demonstrate low micromolar to submicromolar ic50 values against human molt 4/c8 and cem t-lymphocytes and murine leukemia l1210 cells. in this study, a comparative qsar investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

the biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy- 5,6-dihydro prodrugs to s-ethyl-2'-deoxyuridine (edu) including (-)-trans-(5s, 6s)-s-bromo-s-ethyl-6-methoxy-s, 6-dihydro-2'-deoxyuridine (bmedu), (+ )-trans( sr, 6r)-s-bromo-s-ethyl-6-ethoxy-s, 6-deoxyuridine (beedu), (+ )-trans-(sr, 6r)-5-bromo-5-ethyl-6-ethoxy -s, 6-dihydro-s '-o-valeryl-2 ':.de...

abstract: according to the statistics over 30000 deaths occur annually in iran due to cancer with an incidence of over 70000 new cases; this growing rate is similar to the developing world. these figures do not take into account other chronic illnesses like diabetes, heart failure, gastro-intestinal disorders, chronic neurological disorders and lung disease, which all warrant palliative care. a...