The cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule on T cells acts to maintain homeostasis by regulating the proliferation of recently activated T cells. Blockade of CTLA-4 by anti-CTLA-4 antibody enhances T cell responses and has elicited significant tumor regression in some cancer patients. Clinical trials are ongoing to investigate the efficacy of anti-CTLA-4 antibody as a cancer therape...

1Memorial Sloan-Kettering Cancer Center, New York, USA 2H. Lee Moffitt Cancer Center, Tampa, FL, USA 3The Angeles Clinic and Research Institute, Santa Monica, CA, USA 4AP-HP, Hôpital Saint-Louis, Service de Dermatologie; Université Paris Diderot Paris7, INSERM U976 Skin Research Center, Paris, France 5University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy 6University Hospital Essen...

Resected carcinoma patients were immunized 3-5 times with ovine submaxillary gland mucin (OSM) containing predominantly sialylated Tn (sTn), completely desialylated ovine submaxillary gland mucin (dOSM) containing predominantly Tn, or 50% desialylated OSM containing Tn and sTn plus bacillus Calmette-Guerin (BCG) as an immunologic adjuvant. Preand postimmunization sera were quantified by ELISA, ...

We study the properties of geodesic currents on free groups, particularly the " intersection form " that is similar to Bonahon's notion of the intersection number between geodesic currents on hyperbolic surfaces .

1Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY, USA 2Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA 3Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA 4Ludwig Institute for Cancer Research, New York Branch, Memorial Sloan-Kettering Cancer Center, New Yor...

Both nanophotonics and plasmonics concern investigations into building, manipulating, and characterizing optically active nanostructures with a view to creating new capabilities in instrumentation for the nanoscale, chemical and biomedical sensing, information and communications technologies, enhanced solar cells and lighting, disease treatment, environmental remediation, and many other applica...

The highly restricted distribution of human folate receptor-alpha (FRα) in normal tissues and its high expression in some tumors, along with its putative role in tumor cell transformation, make this antigen a suitable target for antigen-specific, monoclonal antibodybased immunotherapy for oncology indications. We have developed a therapeutic humanized monoclonal antibody with high affinity for ...

1Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Warren 827, Boston, MA 02114, USA 2Department of Medicine, Section of Dermatology, University of Chicago, 5841 S. Maryland Avenue, MC 5067, Chicago, IL 60637, USA 3Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 200, Boston, MA 02114, U...

BACKGROUND The present study was undertaken to establish any correlation of elevated levels of CA19-9 with tumor stage or grade of urothelial carcinoma. MATERIALS AND METHODS This hospital based study was carried out in the Department of Biochemistry of Nepalese Army Institute of Health Sciences between 1st July 2012 and 31st December 2012. Approval for the study was obtained from the institu...

A straightforward calculation reveals the essentially nonlocal character of the leading heavy Q Q interaction arising from nonperturbative gluon eld correlations in the model of a uctuating QCD vacuum. In light of this quarkonium spin splitting ratio predictions which have supported the scalar connnement ansatz are reconsidered as a speciic example of possible consequences for spectroscopy. A g...