Recent studies showed that oxytocin plays an important role in nociceptive modulation in the central nervous system. The present study was undertaken to investigate the role of oxytocin in antinociception in the nucleus raphe magnus (NRM) of rats and the possible interaction between oxytocin and the opioid systems. Intra-NRM injection of oxytocin induced dose-dependent increases in hindpaw with...

Introduction: The aim of the present study was to evaluate the effect of oxytocin on the angiogenesis and inflammatory parameters in air pouch model of inflammation. Methods: Inflammation was induced by injection of carrageenan into pouches in male Wistar rats. Oxytocin (4.25, 8.5 and 17 μg) was administered intra pouch at the same time as the carrageenan and then for 2 consecutive days. Af...

In this review, we consider the ways in which vasopressin and oxytocin have been measured since their first discovery. Two different ways of measuring oxytocin in widespread use currently give values in human plasma that differ by two orders of magnitude, and the values measured by these two methods in the same samples show no correlation. The notion that we should accept this seems absurd. Eit...

BACKGROUND Intrauterine fetal death is a major problem in obstetrics particularly in developing countries such as Uganda. Induction of labour in cases of fetal death using the available method of oxytocin is often difficult, expensive and frustrating. OBJECTIVES To compare the effectiveness of vaginal misoprostol and intravenous oxytocin in induction of labour in women with intrauterine fetal...

In the study of the relationship between structure and biological activity in the neurohypophysial hormones, oxytocin and vasopressin, attention has recently been focused in this and other laboratories on the chemical functional groups. Aside from peptide linkages, these chemical functional groups in oxytocin consist of a primary amino, a phenolic hydroxyl, three carboxamide groups, and a disul...

Yu-Feng Wang Pulsatile release of hormones and neurotransmitters is widespread in mammals and typical of oxytocin secretion during lactation. Sucklingevoked pulsatile release of oxytocin follows a transient activation of hypothalamic oxytocin neurons in a burst-like firing pattern and leads to a bolus release of oxytocin and milk ejections. Prostaglandin (PG), a nonhormonal messenger cytokine, ...

Oxytocin has been proposed to regulate human trust. Previous experiments supported this claim by demonstrating that exogenous and endogenous oxytocin is associated with trust (how much people place in strangers) reciprocity reciprocate when trusted). However, recent replication attempts have unsuccessful the trust-enhancing effect of oxytocin, there limited evidence on whether reciprocity. This...

Enriched plasma membranes from uterine smooth muscle of estrogen-treated rats were prepared by discontinuous sucrose gradient centrifugation. This specific fraction contained oxytocin receptors and oxytocin-inhibited calcium-stimulated and magnesium-dependent adenosine-triphosphatase ((Ca + + Mg2+)ATPase) activity. Membranes from myometria of rats treated with progesterone lacked both basal and...

Background: To evaluate the effect of oxytocin on blood circulation of fetus and uterus by Doppler ultrasound. Materials and Methods: Forty six pregnant women were assigned to receive for indication of delivery intravenous oxytocin. Doppler velocitometry before and after administration of oxytocin for umbilical,middle cerebral artery and uterine artery were performed, and Pulsatility index (PI)...

Oxytocin is used widely for the induction and augmentation of labour, but there is little information about the dynamics of oxytocin receptors in human myometrium during parturition, and the possible effect of oxytocin infusion. This information is important because G protein-coupled receptors, such as the oxytocin receptor, undergo desensitization after prolonged or repeated stimulation. The c...