Replacement of invasive monitoring of cerebral venous oxygenation with noninvasive techniques offers great promise in the management of life-threatening neurologic illnesses including traumatic brain injury. We developed and built an optoacoustic system to noninvasively monitor cerebral venous oxygenation; the system includes a nanosecond Nd:YAG laser and a specially designed optoacoustic probe...

BACKGROUND Extracorporeal membrane oxygenation is an established life-saving procedure for severe acute respiratory failure due to various causes. In general, the duration of extracorporeal membrane oxygenation ranges from 1 to 2 weeks, with withdrawal recommended if no improvement is noted. We report a successful case of long-term extracorporeal membrane oxygenation management for respiratory ...

OBJECTIVE Neurologic sequelae remain a well recognised complication of paediatric cardiac surgery. Monitoring of cerebral oxygenation may be a useful technique for identifying vulnerable periods for the development of neurologic injury. We sought to measure regional cerebral oxygenation in children undergoing cardiac surgery using near infrared spectroscopy to ascertain such vulnerable periods....

Background Airway management is a core clinical skill in anaesthesia. Pre-oxygenation prior to induction of anaesthesia is a standard practice to prevent desaturation. Apnoeic oxygenation in adults is effective and prolongs the time to desaturation. The effectiveness of apnoeic oxygenation in the adult is well documented; however, evidence in the paediatric is lacking. Therefore, the aim of thi...

Introduction The pathophysiology of chest pain in patients with Syndrome X remains controversial. Previous studies using nuclear techniques or CMR to assess myocardial perfusion have shown conflicting results. Advances in perfusion imaging with CMR now enable absolute quantification of regional myocardial blood flow. Furthermore, blood oxygenation level-dependent (BOLD) CMR provides the unprece...

We report on a successful configuration strategy of extracorporeal membrane oxygenation(ECMO) in two consecutive cases of acute lung injury. A 60-year-old woman with Streptococcus pneumoniae infection and a 22-year-old man with hemothorax were admitted to our hospital with failing lungs. Although treatment with a ventilator was started, oxygenation could not be maintained. ECMO with a femoro-fe...

The most basic goal of anaesthetists and intensivists is to assure that there is an adequate supply of oxygen to the mitochondria throughout the body to maintain aerobic metabolism and cellular function. The determination of adequate oxygenation has historically been monitored by the absence of organ dysfunction because techniques were not available to assess quantitatively the oxygenation of t...

Setting inspired oxygen fraction (FiO ) is a complicated balance between ensuring adequate 2 oxygenation and minimizing the risk of lung damage. This paper presents a retrospective test of a modelbased decision support system (INVENT) for advising on FiO levels in intensive care patients. Clinically determined FiO levels and the resulting blood oxygenation are compared with INVENT determined Fi...

BACKGROUND Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation and improve oxygenation during the ensuing anaesthesia. METHODS We randomly assigned 24 patients to either a control group (n = 12) or an intervention group (n = 12) receiving...

We compared the test-retest reliability of near-infrared spectroscopy (NIRS) measures of cerebral oxygenation and blood volume during a rhythmic handgrip exercise in 13 nondisabled subjects and 25 subjects with moderate to severe traumatic brain injury (TBI). Subjects with TBI (average Glasgow Coma Scale score = 4.2, average time since injury = 21 mo) had completed an acute brain injury rehabil...