A series of oxime ether and oxime ester derivatives of the potential anti-Parkinson prodrug PD148903 (2.3) were synthesized and evaluated in pharmacological models. Oximes 4.3 (hydroxyl-oxime) and 4.4 (methoxyl-oxime) were inactive in vitro but in the Ungerstedt rat model for Parkinson’s disease 4.3 and 4.4 produced a pronounced and long lasting effect at 1.0 mg kg po. Enantiomerically pure (–)...

Mini-chromosome maintenance complex-binding protein (MCM-BP) was discovered as a protein that is strongly associated with human MCM proteins, known to be crucial for DNA replication in providing DNA helicase activity. The Xenopus MCM-BP homologue appears to play a role in unloading MCM complexes from chromatin after DNA synthesis; however, the importance of MCM-BP and its functional contributio...

We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poiso...

Önemli bir hammadde olan izobütene her geçen gün talebin artması, izobütan dehidrojenasyonunu dikkat çekici konuma getirmiştir. Endotermik denge limitasyonlu bu reaksiyon için katalizör sentezi son derece önemlidir. Cr temelli katalizörler monokromatların en aktif tür olduğu bilinmektedir. Bu çalışmada, içeriğinin Cr@MCM-41 yapısına, kromat türleri ve miktarları üzerine etkilerinin araştırılmas...