INTRODUCTION The aim of this study was to evaluate the serum paraoxonase (PON), arylesterase activities, lipid hydroperoxide (LOOH), sulfhydryl (-SH), and ceruloplasmin (Cp) levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in adults with obstructive sleep apnea syndrome (OSAS) and to determine whether these oxidant and antioxidant levels can b...

Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism, mainly through the mitochondria and peroxisomes, but their release is enhanced by the activation of oxidant enzymes such as NADPH oxidases or downregulation of endogenous antioxidant enzymes such as manganese-superoxide dismutase (MnSOD) and catalase. Transforming growth factor-β (TGF-β), found to be overexpr...

Chelation therapy is thought to not only remove contaminating metals but also to decrease free radical production. However, in standard ethylene diamine tetracetic acid (EDTA) chelation therapy, high doses of vitamin C with potential pro-oxidant effects are often added to the chelation solution. The authors demonstrated previously that the intravenous administration of the standard chelation co...

Background: Polycystic Ovarian Syndrome (PCOS) is a common endocrinological problem that leads to infertility in reproductive age. It strongly associated with oxidative stress, which increases the risk of Metabolic (Met-S) women. This study aimed evaluate relationship between stress markers and metabolic syndrome parameters PCOS Methods: In this cross-sectional study, we included age-matched 10...

WE COMPARED THREE GROUPS OF PREGNANT WOMEN: placebo with normotensive women, group A which included preeclamptics, and group B which comprised preeclamptics who were supplemented their diets with vitamins C and E. MDA increased from 6.22 +/- 2.8 (placebo) to 8.48 +/- 1.2 (A) and 8.02 +/- 1.8 nmol/gHb (B). NO concentrations were enhanced from 19.3 +/- 4.2 (P) to 23.8 +/- 6.4 (A) and 24.1 +/- 5.4...

In the pathogenesis of asthma, oxidative stress appears to play an important role and existence of an oxidant/antioxidant imbalance is evident. In this study the key markers of oxidative stress and lipid peroxidation in the pathogenesis of asthma in childhood in comparison to healthy subjects were investigated. Plasma marker of the lipid peroxidation: malondialdehyde (MDA), the erythrocytes ant...

Liver steatosis can evolve to steatohepatitis (NASH) through a series of biochemical steps related to oxidative stress in hepatocytes. Antioxidants, such as silybin, have been proposed as a treatment of patients with nonalcoholic fatty liver disease (NAFLD) and NASH. In this study, we evaluated, in patients with histologically documented NASH, the oxidant/antioxidant status and lipid "fingerpri...

background:  the development of nanotechnology has been a boon to mankind as its significance paved the way for several applications in therapeutics. this study was to evaluate the anti-arthritic capability of nano selenium-lovastatin mixture (lov-se) against inflammatory cascade in arthritic irradiated rats. materials and methods: animal model of arthritis was organized by subcutaneous injecti...

BACKGROUND In the general population, reported levels of oxidative stress and antioxidant potential seem to vary. The aim of this study was to investigate the levels of oxidant status markers in relation to estimated glomerular filtration rate (eGFR) and albuminuria in Japanese population. METHODS Data were analyzed from 8335 individuals who underwent a general health screening test. For the ...

Nephrotic patients show various abnormalities in protein kinetics. Plasma albumin levels and the total plasma albumin pool are reduced. Nephrotic syndrome is a consequence of an imbalance between oxidant and anti-oxidant activity. Oxidative damage has been proposed as one of the possible mechanism involved in the Nephrotic syndrome. Therefore, this study was carried out to investigate oxidant a...