Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...

objective(s):in the present study, we evaluated immunological and immunomodulatory properties of royal jelly (rj) in 2,4,6 trinitrobenzene sulfonic acid (tnbs)-induced colitis in rats. materials and methods: eighteen adult female wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a tnbs-induced colitis group, and a tnbs-col...

At present, laboratory animals are not standardized with regard to the gastrointestinal microbiota (GM), but differences in this feature may alter various parameters in animal models. We hypothesized that variation in the GM correlated with variation in clinical parameters of a murine oxazolone-induced skin inflammation model of atopic dermatitis. BALB/cA mice were sensitized with oxazolone ov...

Nanoparticles (NP) are proposed for targeted drug delivery to the inflammation site in severe cases of inflammatory bowel disease where state-of-the-art delivery devices fail. FK506 (tacrolimus) entrapped into NP was administered either orally or rectally to male Wistar rats suffering from a preexisting experimental colitis. Clinical activity score, colon/body weight index, and myeloperoxidase ...

the main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. pellet cores of budesonide were prepared by extrusion / spheronization technique. pectin, in different ratios was combined with eudragit rs30d, eudragit ne30d or surelease to produce film coating. the dissolution profiles of pectin coated pellets were investigated in ph of 1.2 (2 ...

psychological disorders such as depression have more prevalence in inflammatory bowel disease patients and can exacerbate the clinical course of the disease, so anti-depressant therapy may have a potential to positively impact the disease course. on the other hand several antidepressant drugs have shown anti-inflammatory and immunomodulatory properties. thus, this study aimed to explore the ben...

The development of contact hypersensitivity (CHS) greatly depends on the allergenicity of the inducing agent. However, various cofactors are known to influence the outcome of the response as well. From this perspective, we have compared the effects of five different vehicles: acetone, ethanol, dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), and a 4 to 1 mixture of acetone and olive oil (AO...

Objective(s): This study was aimed at investigating immune activations of the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in colonic mucosa by immunohistochemical and Western blot methods. Materials and Methods: For this purpose, 16 female Wistar albino rats were divided into two random groups of control (n=8) and colitis (n=8). The experimental colitis model was induced by...

Figure 1. (A) The b5 ion is generated by collision induced dissociation resulting in formation of the oxazolone ring through attack of the oxygen lone pair on the newly formed terminal carbonyl group. (B) N-terminal nucleophilic attack of the oxazolone ring to form the macrocycle. (C) The resultant macrocyclic intermediate undergoes ring opening to give sequence scrambled b5 ions. N.B. Numberin...