As observed with nitric oxide (NO), carbon monoxide (CO) binds and may activate soluble guanylate cyclase and increase cGMP levels in smooth muscle cells in vitro. Because inhaled NO (I(NO)) causes potent and sustained pulmonary vasodilation, we hypothesized that inhaled CO (I(CO)) may have similar effects on the perinatal lung. To determine whether I(CO) can lower pulmonary vascular resistance...

Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18(31), CAP18(28), CAP18(22), and CAP18(21a) were the most active, with MICs as low as 0.6 microg/ml. Other cathelicidins were less active. ...

We used competitive thromboxane A2-prostaglandin endoperoxide receptor blockade (SQ 30,741) as a probe to evaluate the role of thromboxane in ovine pulmonary vasoconstriction associated with protamine reversal of heparin anticoagulation. Control heparin-protamine reactions induced rapid release of thromboxane into arterial plasma (more than 1 ng/ml plasma), a 2.5-fold increase of pulmonary arte...

Both an external nasal strip device (FLAIR) and furosemide significantly attenuated pulmonary hemorrhage in Thoroughbred horses following a 2-minute bout of high-speed treadmill exercise. Given the purported ergogenic effects of furosemide and the general concerns associated with drug use in racehorses, the external nasal strip is a viable alternative for the attenuation of exerciseinduced pulm...

The operation of pulmonary valvotomy has been so brilliantly successful that its failure to achieve an ideal end result in certain cases deserves comment. In this report, some residual effects of isolated pulmonary stenosis that may persist after complete valvotomy will be considered. It will be seen that all of these are the result of very severe stenosis or of long-delayed relief of stenosis ...

Ovine pulmonary adenocarcinoma (OPA) can be reproduced consistently in neonatal lambs by intratracheal injection of inocula containing jaagsiekte sheep retrovirus (JSRV). In this study, clinical disease, confirmed pathologically as OPA, was induced in a high proportion of lambs that had been inoculated intratracheally with infectious lung fluid at 1, 3 and 6 months of age. The incubation period...

Pulmonary cryptococcosis (PC) is an opportunistic and conditional disease. It commonly occurs in immunocompromised patients. We presented a case of PC in an immunocompetent patient. This patient had the complaints of irritating cough and shortness of breath. A variety of antibiotic treatment was ineffective. The patient eventually received percutaneous transcutaneous biopsy and PC was diagnosed...

Pulmonary tuberculosis is a major flail of mankind, 1/3 of the world population is infected. In Morocco, the incidence is estimated by the Word Health Organization to 89 cases per 100 000 inhabitants. However, gunshot assaults are rare. Many circumstances of discovery of tuberculosis were described. We present the case of an incidental finding of pulmonary tuberculosis in a young patient victim...

The natural history of cystic fibrosis lung disease is one of chronic progression with intermittent episodes of acute worsening of symptoms frequently called acute pulmonary exacerbations These exacerbations typically warrant medical intervention. It is important that appropriate therapies are recommended on the basis of available evidence of efficacy and safety. The Cystic Fibrosis Foundation ...

Idiopathic pulmonary fibrosis is a chronic actively progressive disease of unknown etiology. Prognosis of the disease in the majority is unfavorable, the condition of patients failures rapidly. Life expectancy after diagnosis is from 2 to 4 years [1,2]. The current set of therapeutic interventions for pulmonary fibrosis is limited and not effective. Clinical practice focuses primarily on the tr...