background: iron chelators are an important part of management of patients with thalassemia. it is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. we aimed to compare the efficacy and safety of available oral iron chelator; deferasirox (exjade®) with deferasirox (osveral®) in reducing iron overload in...

BACKGROUND High rates of volume overload hospitalizations may indicate inadequate dialysis facility fluid management. Administrative claims databases are often used to study such outcomes, but these data are generated for billing purposes and may not capture clinical nuance. It is unknown if volume overload admissions can be correctly identified in administrative data and if a single claims-bas...

The amount of email people have to deal with is overwhelming. People tend to work extra hours in order to keep up with their email, and some are even getting ill because of all the stress this overload generates. This paper describes the causes and symptoms of email overload, the strategies people use to deal with it and possible solutions towards the problem. These are given with the help of a...

Design, setting, participants, & measurements Fluid status was optimized prospectively in 55 chronic hemodialysis patients over 3 months (November 2011 to February 2012). Predialysis fluid overload was measured weekly using the Fresenius Body CompositionMonitor. Time-averaged fluid overload was calculated as the average between preand postdialysis fluid overload. The study aimed to bring the ti...

Wireless networks are currently experiencing more overload situations than their wireline counterparts because of explosive mobile traffic growth, unpredictable traffic behavior, service differentiated traffic shedding, etc. Even though extensive research work on network overload control in general is going on, the economic aspect of the overload problem has received very little attention. Mana...

Mobile Switching Centers (MSCs) in wireless telecommunication networks must implement signaling overload controls to maintain acceptable performance during periods of high load especially due to fast changing hot spots resulting from user mobility. An MSC’s signaling load comprises a variety of service requests, some more important than the others, and it must treat them differentially under ov...

The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy. Liver tissue samples from 95 patients with chronic hepatitis C were divided into two groups: group I, presence of iron overload in hepatic tissue (Perls' staining) and group II, no ...

OBJECTIVE The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients. METHODS A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratified into two groups, according to the presence of iron overload: Iron ov...

AIM To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPIII criteria. Iron overload was assessed by liver biopsy. Liver histology was e...

Dietary copper in the U.S. often is lower than that proved insufficient for men and women under controlled conditions. Iron overload can have adverse effects on copper nutriture and can produce cardiac disease in people. The hypothesis that iron can interfere with copper utilization to produce adverse effects related to cardiovascular function was tested. Rats were fed a diet high in iron and m...