One key bottleneck of solid-state NMR spectroscopy is that 1H spectra organic solids are often very broad due to the presence a strong network dipolar couplings. We have recently suggested new approach tackle this problem. More specifically, we parametrically mapped errors leading residual broadening into second dimension and removed them in correlation experiment. In way pure isotropic proton ...

Introduction: GABA is the major inhibitory neurotransmitter in mammalian brain and GABAergic alterations have been implicated in several psychiatric and neurological disorders. GABA was also proposed to underlie DFM modulation (1). Because of this growing interest in understanding physiology and pathophaysiology of cerebral GABA homeostasis, there is a need for robust measurement of in vivo GAB...

In this work, a comprehensive methodology for the fitting of single-walled carbon nanotube absorption spectra is presented. Different approaches to background subtraction, choice of line profile, and calculation of full width at half-maximum are discussed both in the context of previous literature and the contemporary understanding of carbon nanotube photophysics. The fitting is improved by the...

Background: Survivin is an integral part of the Chromosomal Passenger Complex (CPC) which plays a vital role in mitosis. Experiments have demonstrated that survivin can physically bind to DNA. Crystallographic studies show binds Threonine-3 histone H3. In patients with autoimmune diseases, increased expression contributes aggravated disease phenotype. Thus, functional, and mechanistic data poin...

In addition, we have taken advantage of GSD to implement under Mnova the quantitative referencing strategy known as PULCON [5]. It is well known that when dealing with biological samples containing lipids and proteins, one can not use an internal standard to perform absolute quantification of metabolites. This is due to the fact that all possible reference compounds (such as TSP or DSS) interac...

We examined the attentional sensitivity of the frequency-change mismatch negativity (MMN). Subjects listened to a binaural mixture of a narrative and a series of tone bursts that included 1200-Hz standards and two deviants (1000 and 1400 Hz). In the attend-tones condition, subjects responded to one deviant and ignored the narrative. In the attend-words condition, subjects responded to target wo...

In absorption chromatography, fused peaks may arise due to incomplete resolution of two or more eluting species. In figure 1, the chromatogram of an inorganic multicomponent polluting substance, acquired by means of a Dionex Ionic chromatographic system, is shown. The problem consists in quantitative evaluation of fluorine content, whose retention time is 3 mn, on the basis of the measured chro...

Multivariate calibration based on a suitable experimental design (ED) and soft modelling with artificial neural networks (ANNs) is proposed for quantitative analysis of highly overlapped and disturbed differential pulse polarographic (DPP) peaks that occur in the region of a hydrogen evolution. It is demonstrated that analysis of mixtures, even if some of the constituents undergo an irreversibl...

Submovements are hypothesized building blocks of human movement, discrete ballistic movements of which more complex movements are composed. Using a novel algorithm, submovements were extracted from the point-to-point movements of 41 persons recovering from stroke. Analysis of the extracted submovements showed that, over the course of therapy, patients' submovements tended to increase in peak sp...