Alterations in p53 and Rb pathways are observed frequently in epithelial ovarian cancer (EOC).However, their roles in EOC initiation remain uncertain. Using a single intrabursal administration of recombinant adenovirus expressing Cre, we demonstrate that concurrent inactivation of p53 and Rb1 is sufficient for reproducible induction of ovarian epithelial carcinogenesis in mice homozygous for co...

Sertoli leydig cell tumors are exceedingly uncommon tumors of the ovary accounting for less than 0.5% of all ovarian neoplasms and 1% of sex cord tumors. These tumors are functional and secrete testosterone and only rarely they are estrogenic. Hence the patients present with virilization features. Most of the tumors are unilateral and bilaterality is extremely rare. Here we report an unusual ca...

Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity o...

The role of the clinical laboratory in the diagnosis of abnormalities in gonadal development is reviewed, beginning with a description of the normal differentiation of the ovary and testis and the major types of disorders encountered. The conditions are classified as resulting from abnormal gonadal differentiation, defective endocrine function or excessive endocrine activity. Germ cell neoplasm...

Ovarian metastasis was described the first time by Friedrich Ernst Krukenberg in 1896. Even if the historical timeline dates back to sir James Paget who had described the process in 1854 [1]. The tumor was metastazing from gastric cancer. Consequently, all metastatic ovarian cancers had been referred to as Krukenberg tumors [2]. Actually, Krukenberg tumors account for approximately 15% of malig...

The primary aim of type 2 diabetes mellitus treatment is to achieve and maintain good glycemic control, and to minimize the mortality and risk of microvascular and macrovascular complications. Current algorithms for medical management of type 2 diabetes mellitus recommend a combination of lifestyle intervention and metformin as initial therapy and ‘gold standard’ treatment. Numerous studies sug...

Neoplasms of the ovary are the cause of more deaths than any other female cancer. Approximately 23% of all gynaecological cancer are of ovarian origin, but 47% of all deaths from cancer of the female genital tract are due to ovarian carcinoma. Combination systemic chemotherapy frequently produces startling remissions and yet the overall five year survival rate remains 25%, the lowest survival s...

Mature cystic teratomas are benign ovarian neoplasms which account for around 95% of all ovarian germ cell tumours and contain tissues derived from two or three embryonic germ layers. These tumours are frequently diagnosed in women of reproductive age group and can result in fetomaternal distress if concurrent pregnancy occurs. The authors describe a case of successful natural pregnancy in a 30...

Sertoli Leydig Cell Tumours (SLCTs) are rare, unilateral, sex cord stromal tumours of ovary, which constitute less than 1% of all the ovarian neoplasms. These tumours can be functionally diverse and they may have heterologous elements. We aim to report a case of a 25-year- old woman who presented with suprapubic pain of 5 days duration, a unilateral adnexal mass, hypertestosteronism without vir...

UNLABELLED BACKGROUND Mature cystic teratomas (MCTs) are the most common germ cell tumors of the ovary. Malignant tranformation occurs in 1-2% of these neoplasms. Although most of the malignancies arising from MCTs are squamous cell carcinomas, adenocarcinoma of the gastrointestinal type is extremery rare. We herein present a case of adenocarcinoma of the intestinal type arising from a MCT. ...