the premature and age-induced ovarian failure are associated with significant medical and quality of life complications. Moreover, millions of children and adults suffer from iatrogenically-induced premature gonadal failure as a result of chemotherapy treatments. In the case of chemotherapy, commonly used cancer drugs such as doxorubicin or cyclophosphamide result in apoptotic death of primordi...

In this study, we characterized the metabolome of the human ovary and identified metabolic alternations that coincide with primary epithelial ovarian cancer (EOC) and metastatic tumors resulting from primary ovarian cancer (MOC) using three analytical platforms: gas chromatography mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) using buffer systems and in...

OBJECTIVE We compared survival outcomes of advanced serous type epithelial ovarian cancer (EOC) patients with normal-sized ovaries and enlarged-ovarian tumors by propensity score matching analysis. METHODS The medical records of EOC patients treated at Samsung Medical Center between 2002 and 2015 were reviewed retrospectively. We investigated EOC patients with high grade serous type histology...

Chemoprevention or the now more preferred 'cancer prevention' is the long-term administration of a biological or chemical agent to reduce the risk of cancer. This approach has long been active in individuals at high risk of developing breast or colon cancer. The aim of this expert meeting was to review the current status of the field of cancer prevention and potential, emerging biomarkers speci...

The third most common cancer in the United States, lung cancer, is the leading cancer killer of both men and women.[1] Because of the low cure rate (14%), lung cancer kills more individuals than cancers of the breast, prostate, colorectum, and ovary combined.[1] Less than 25% of lung cancer patients present with stages I and II, and nearly all patients die with disseminated systemic disease. Th...

background: peritoneal tuberculosis accounts 1-2% of all forms of tuberculosis. peritoneal tuberculosis is an important differential diagnosis for ovarian cancer in women with ascites, adnexal mass and elevated cancer antigen 125 (ca125) levels. we report a case of a 32- year -old woman with multiple miliary peritoneal deposits mimicking advanced ovarian carcinoma. case presentation: a 32-year-...

Background: Pollution and genetic factors have increased the likelihood of cancer in developing world. Cancer is now leading cause death young patients. Scientists are focusing on new treatments with a lower risk profile than traditional cytotoxic drugs. Nigella sativa (black seed) has been used for centuries by ancient cultures to treat variety ailments. Thymoquinone, main active compound foun...

Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. During normal development of the Drosophila ovary, a dynamic process called border cell migration occurs that resembles the migratory behavior of human ovarian cancer cells. In this study, we found that myosin VI, a motor protein that regul...

Ovarian cancer arising from an ovarian endometriotic cyst is frequently encountered; however, this condition has rarely been reported in young patients. We herein report a case of malignant transformation of an ovarian endometriotic cyst in a 26-year-old woman (gravida 0, para 0). During the initial examination at our hospital, ultrasound revealed an endometriotic cyst in the right ovary measur...

Risk-reducing salpingo-oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention in BRCA1/2 mutation carriers. Occult fallopian tube and ovarian cancers have been reported in a small percentage of BRCA1/2 mutation carriers undergoing RRSO. Here, we review our single-institution experience with RRSO in BRCA1/2 mutation carriers to characterize cases of microscopic cancers in these pati...