نتایج جستجو برای: ovarian follicles

تعداد نتایج: 87629  

Journal: :Reproduction 2008
Gretchen Dole Eric E Nilsson Michael K Skinner

Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line-derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from 4-day-old female rat pups were maintained in organ culture for 10 days in the absence (control) or presence of GDNF or kit ...

Asmatullsh, A Mubarak Khalid , K Raees Ahmad , N Tawakal , U Farooq Khan ,

Introduction:Artifical sourace of radiation have increased worldwide average annual exposure of mankind and could especially affect rapidly dividing cells in gonads. Since, radiation sensitivities of different components of primordial follicles, and the time required for their deplation have not been morphologically eatablished we decided to estimate the time required for depletion of primordi...

Journal: :Endocrinology 2000
Hyun-Jeong Park Jin Lee Li Wang Jeong-Hoh Park Hyuk-Bang Kwon Akira Arimura Sang-Young Chun

Expression of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with considerable homology to vasoactive intestinal peptide, has been shown to be stimulated by gonadotropins in the ovary. The present studies further evaluated the cell-type specific expression and gonadotropin regulation of PACAP type I receptor (PACAPR) messenger RNA in immature rat ovaries and in cultu...

Journal: :Reproduction, nutrition, development 1994
M A Driancourt

Follicular growth over 2 mm in diameter is mainly regulated by gonadotrophins (FSH and LH). However, it is possible that between-follicle interactions may be involved in ensuring ovulation of a specific number of follicles. The present study tested specific hypotheses regarding: (1) a stimulatory role of atretic follicles on differentiation of follicles of the next wave; (2) a stimulatory role ...

Journal: :Developmental biology 2006
Sarah K Bristol-Gould Pamela K Kreeger Christina G Selkirk Signe M Kilen Kelly E Mayo Lonnie D Shea Teresa K Woodruff

The importance of the initial follicle pool in fertility in female adult mammals has recently been debated. Utilizing a mathematical model of the dynamics of follicle progression (primordial to primary to secondary), we examined whether the initial follicle pool is sufficient for adult fertility through reproductive senescence in CD1 mice. Follicles in each stage were counted from postnatal day...

Journal: :Frontiers in bioscience 2011
Ge Li Hua Zhang Yijing Wang Jing Wen Zhen Teng Guanping Mao Jianwei Wang Meng Guo Xinyi Mu Guoliang Xia

Although recent studies have shown that female germ cells can be produced from stem-cell lines in mice, whether these germ cells can interact with ovarian somatic cells (OSCs) to form primordial follicles (PFs) is still unclear. Here, we found after the PF pool is established, Irx3 and FoxL2 which were extensively expressed in the OSCs of the perinatal mouse decreased. Additionally, during prim...

Journal: :cell journal 0

objective: the purpose of the present study was to verify the ultrastructural characteristics of cultured mouse preantral follicles from fresh and vitrified –warmed ovarian tissues. materials and methods: the ovaries of 14-day-old mice (n = 5) were vitrified using a mixture of ethylene glycol, ficoll 70 and sucrose. the preantral follicles were isolated and cultured in α-minimum essential mediu...

Journal: :International journal of oncology 2008
Tomoko Utsunomiya Tetsuji Tanaka Hirotoshi Utsunomiya Naohiko Umesaki

Clinical use of CPT-11 combination chemotherapy frequently induces ovarian dysfunction in premenopausal and perimenopausal cancer patients, but its mechanism remains unclear. Mouse experiments were performed to clarify the molecular mechanism of CPT-11-induced ovarian dysfunction. Clinically therapeutic doses of CPT-11 were injected intraperitoneally into 8-week-old female MCH mice, and their o...

Journal: :The Journal of endocrinology 2003
F Shi P S LaPolt

FoxO1 is a transcription factor implicated in a growing number of physiological processes, including apoptosis, cell cycle progression, and insulin signaling. Recent findings indicate that FSH and growth factors influence ovarian functions in part through regulation of FoxO1. The present study utilized immunohistochemical analysis to determine the ovarian localization and regulation of FoxO1 pr...

2015
Ying Li Ying Fang Ying Liu Xiaokui Yang

MicroRNAs (miRNAs) are endogenous, small, noncoding single-stranded RNA molecules approximately 22 nucleotides in length. miRNAs are involved in the post-transcriptional regulation of various important cellular physiological and pathological processes, including cell proliferation, differentiation, apoptosis, and hormone biosynthesis and secretion. Ovarian follicles are the key functional units...

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