Thyroid gland dysfunction is associated with disorders of female reproductive functions. The aim of this study was to examine the effects of hyperthyroidism on ovulation rate and peripheral sex steroid levels in prepubertal and adult rats. Two groups of female rats aging 30 days (prepubertal rats) and 60 days (adult rats) were made hyperthyroid by oral administration of levothyroxine daily...

Background With aging, the ovarian reserve is decreased and that is a major contributor to poor ovarian response to exogenous gonadotropins. The aim of the present study is to evaluate the role of Dexamethasone on ovarian response in infertile patients aged over 35 years undergoing IVF/ICSI cycles. MaterialsAndMethods In this triple blind placbo-control clinical trial study, a total of 72 infer...

BACKGROUND Life history models suggest that biological preparation for current versus longer term reproduction is favored in environments of adversity. In this context, we present a model of reproductive aging in which environmental adversity is proposed to increase the number of growing follicles at the cost of hastening the depletion of the ovarian reserve over time. We evaluated this model b...

Several studies have demonstrated that anti-Müllerian hormone (AMH) is a better marker of ovarian reserve than age, basal FSH, estradiol and inhibin. AMH is very good in (i) predicting both over- and poor-response in the controlled ovarian stimulation environment, (ii) determining the most appropriate stimulation regimen and (iii) pre-treatment counselling for couples to make an appropriate and...

OBJECTIVE To compare the ovarian reserve and BMI in fertile and subfertile women aged 20-39 years by ultrasonography. STUDY DESIGN A comparative study. PLACE AND DURATION OF STUDY The Ultrasound Clinic, PECHS, Karachi, from March to December 2006. METHODOLOGY Eighty women, 40 fertile and 40 subfertile, were subdivided into age groups of 20-29 and 30-39 years. Total ovarian volume (OV) was...

The oocyte is the largest cell found in multicellular organisms. Mitochondria, as the energy factories for cells, are found in high numbers in oocytes, as they provide the energy for oocyte maturation, fertilization, and embryo formation via oxidative phosphorylation. Failure of assisted reproduction is mainly attributed to oocyte aging and increased aneuploidy. As the most numerous organelle i...

BACKGROUND Aging contains morphological and functional deterioration in biological systems. D-galactose (D-gal) generates free radicals and accelerates aging. Portulaca oleracea (Purslane) may have protective effect against oxidative stress. OBJECTIVE Purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in D-gal aging female mice. MATERIALS AND METHODS 48...