131I-Labeledgoat immunoglobulin G (IgG) prepared against carcinoembryonic antigen (CEA) was administered at an aver age dose of 1.0 mCi (180 to 250 @glgG protein) to patients with ovarian tumors in order to evaluate this method of tumor detection and localization , termed the radioimmunodetection of cancer. All primary cancers in 13 patients could be localized, whereas the metastases in six of ...

Underwater acoustic sensor networks (UASNs) have become a hot research topic. In UASNs, nodes can be affected by ocean currents and external forces, which could result in sudden link disruption. Therefore, designing a flexible and efficient link disruption restoration mechanism to ensure the network connectivity is a challenge. In the paper, we propose a glider-assisted restoration mechanism wh...

BACKGROUND: Primary surgery followed by platinum-taxane based chemotherapy has been the standard therapy in advanced ovarian cancer. However, the prognostic role of complete and so-called optimal and suboptimal debulking and its interaction with biological factors has not been not fully defined. METHODS: Exploratory analysis was conducted of 3 prospective randomized trials (AGO-OVAR 3, 5, and 7...

BACKGROUND AND METHODOLOGY Combined oral contraceptives (COCs) provide reliable and convenient contraception, although contraindications and tolerability issues may limit their use in some women. Progestogen-only pills (POPs) may be more suitable for some women, however, traditional POPs do not have the same contraceptive efficacy as COCs. A literature search was performed in order to assess th...

We have recently developed an in vitro assay for human tumor stem cells that permits cloning of human ovarian adenocarcinoma cells in soft agar. Tumor colonies grew from both effusions and biopsies from 85% of 31 ovarian cancer patients. The cloning efficiency did not vary with the histology of the tumor. Growth was induced with medium conditioned by the adherent spleen cells of mineral oil-pri...

We have recently developed an in vitro assay for human tumor stem cells that permits cloning of human ovarian adenocarcinoma cells in soft agar. Tumor colonies grew from both effusions and biopsies from 85% of 31 ovarian cancer patients. The cloning efficiency did not vary with the histology of the tumor. Growth was induced with medium conditioned by the adherent spleen cells of mineral oil-pri...

A second tumor suppressor locus on 17p that is distinct from 77*5.1has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCAI and OVCA2, that map to 17pl3.3. The two genes are ubiquitously expressed and encode proteins of 443 and 227 amino acids, respectively, ...

facilitates apoptosis by targeting several anti-apoptotic genes. If miR-466h-5p activation is demonstrated to be a universal early response in apoptotic pathways in CHO, 2 Mü ller, D. et al. (2008) MicroRNAs as targets for engineering of CHO cell factories. Trends Biotechnol. 26, 359–365 3 Xu, X. et al. (2011) The genomic sequence of the Chinese hamster ovar (CHO)-K1 cell line. Nat. Biotechnol....