نتایج جستجو برای: outer hair cells

تعداد نتایج: 1459809  

Journal: :World Journal of Otorhinolaryngology - Head and Neck Surgery 2019

Journal: :Molecular and Cellular Endocrinology 2014
Juliane Dettling Christoph Franz Ulrike Zimmermann Sze Chim Lee Andreas Bress Niels Brandt Robert Feil Markus Pfister Jutta Engel Frédéric Flamant Lukas Rüttiger Marlies Knipper

Thyroid hormone acts on gene transcription by binding to its nuclear receptors TRα1 and TRβ. Whereas global deletion of TRβ causes deafness, global TRα-deficient mice have normal hearing thresholds. Since the individual roles of the two receptors in cochlear hair cells are still unclear, we generated mice with a hair cell-specific mutation of TRα1 or deletion of TRβ using the Cre-loxP system. H...

Journal: :Neuron 2008
Peter Dallos Xudong Wu Mary Ann Cheatham Jiangang Gao Jing Zheng Charles T. Anderson Shuping Jia Xiang Wang Wendy H.Y. Cheng Soma Sengupta David Z.Z. He Jian Zuo

It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophys...

Journal: :ORL; journal for oto-rhino-laryngology and its related specialties 2005
Guihua Liang Ernest J Moore Mats Ulfendahl Bo Rydqvist Leif Järlebark

Potassium M currents play a role in stabilizing the resting membrane potential. These currents have previously been identified in several cell types, including sensory receptors. Given that maintaining membrane excitability is important for mechano-electrical transduction in the inner ear, the presence of M currents was investigated in outer hair cells isolated from the guinea pig hearing organ...

Journal: :Endocrinology 1997
Noriko Obana Chawnshang Chang Hideo Uno

Hair-follicle regression in the bald scalps of stumptailed macaques develops after puberty, which corresponds to an elevation of serum testosterone and dihydrotestosterone. Using the cultured cells from the pre- and postpubertal macaques, we examined the role of dermal papilla cells in testosterone-induced inhibition of outer root sheath cell proliferation. Testosterone showed no effects on pro...

2012
Dingjun Zha Fangyi Chen Sripriya Ramamoorthy Anders Fridberger Niloy Choudhury Steven L. Jacques Ruikang K. Wang Alfred L. Nuttall

BACKGROUND Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating fo...

2016
Tommi Anttonen Anni Herranen Jussi Virkkala Anna Kirjavainen Pinja Elomaa Maarja Laos Xingqun Liang Jukka Ylikoski Axel Behrens Ulla Pirvola

Prevention of auditory hair cell death offers therapeutic potential to rescue hearing. Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with unsolved mechanisms. We have characterized the c-Jun stress response in the mouse cochlea challenged with acoustic overstimulation and ototoxins, by studying the dynamics of c-Jun N-terminal phosphorylation. It ...

Journal: :Journal of neurophysiology 1999
X Hu B N Evans P Dallos

The basilar membrane in the mammalian cochlea vibrates when the cochlea receives a sound stimulus. This mechanical vibration is transduced into hair cell receptor potentials and thereafter encoded by action potentials in the auditory nerve. Knowledge of the mechanical transformation that converts basilar membrane vibration into hair cell stimulation has been limited, until recently, to hypothet...

2016
Tianying Ren Wenxuan He Peter G Barr-Gillespie

It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living ear. Here by directly measuring microstructure vibrations inside the cochlear...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Douglas E Vetter Eleonora Katz Stéphane F Maison Julián Taranda Sevin Turcan Jimena Ballestero M Charles Liberman A Belén Elgoyhen Jim Boulter

Although homomeric channels assembled from the alpha9 nicotinic acetylcholine receptor (nAChR) subunit are functional in vitro, electrophysiological, anatomical, and molecular data suggest that native cholinergic olivocochlear function is mediated via heteromeric nAChRs composed of both alpha9 and alpha10 subunits. To gain insight into alpha10 subunit function in vivo, we examined olivo cochlea...

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