نتایج جستجو برای: outer
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A moda - em Portugal ainda permanece algo remota nos estudos académicos. Poucas são as investigações, de enfoque histórico-social, que se debruçaram sobre a importância da à exceção dos trabalhos Cristina L. Duarte (2016). Procurando obviar esta relativa omissão, propomos um exercício diacrónico – desde finais anos 1970 incidente na relação entre o do-it-yourself (DIY), manifesta nas culturas u...
Abstract We explore the possibilities for elementary embeddings $j : M \to N$ , where and N are models of ZFC with same ordinals, $M \subseteq has access to large pieces j . construct commuting systems such maps between countable transitive that isomorphic various canonical linear partial orders, including real line ${\mathbb R}$
Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria, and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the Bcl-2 family. Here we will consider some very recent data that has shed new insight into the regulation of these proteins and the i...
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
An outer-independent double Italian dominating function (OIDIDF)on a graph $G$ with vertex set $V(G)$ is a function$f:V(G)longrightarrow {0,1,2,3}$ such that if $f(v)in{0,1}$ for a vertex $vin V(G)$ then $sum_{uin N[v]}f(u)geq3$,and the set $ {uin V(G)|f(u)=0}$ is independent. The weight ofan OIDIDF $f$ is the value $w(f)=sum_{vin V(G)}f(v)$. Theminimum weight of an OIDIDF on a graph $G$ is cal...
Pro-apoptotic Bax induces mitochondrial outer membrane permeabilization (MOMP) by forming oligomers through a largely undefined process. Using site-specific disulfide crosslinking, compartment-specific chemical labeling, and mutational analysis, we found that activated integral membrane Bax proteins form a BH3-in-groove dimer interface on the MOM surface similar to that observed in crystals. Ho...
In this paper, we have proposed a numerical method for singularly perturbed fourth order ordinary differential equations of convection-diffusion type. The numerical method combines boundary value technique, asymptotic expansion approximation, shooting method and finite difference method. In order to get a numerical solution for the derivative of the solution, the given interval is divided in...
In this issue, Qi et al. (2016. J. Cell Biol https://doi.org/10.1083/jcb.201609019) provide structural insights into the mechanisms of mitochondrial outer membrane fusion by investigating the structure of mitofusin 1 (MFN1). This work proposes a new model to explain the important and elusive process of MFN-mediated mitochondrial fusion.
Cell death plays an essential role in the development of tissues and organisms, the etiology of disease, and the responses of cells to therapeutic drugs. Here we review progress made over the last decade in using mathematical models and quantitative, often single-cell, data to study apoptosis. We discuss the delay that follows exposure of cells to prodeath stimuli, control of mitochondrial oute...
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