Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron ac...

An 11-year-old boy was found to have primary hyperoxaluria type I (urine oxalate 828mg/l, N 140–420mg/l). His mother had kidney stones and the parents were second degree relatives. After 18 months of dialysis, femoral neck fracture occurred, which was assumed to be related to renal osteodystrophy. During the surgical procedure to fix the fracture site internally, biopsies were taken which showe...

1 Yendt ER. In: Spittel JA, ed. Clinical Medicine. Endocrinology, vol 8. Philadelphia: Harper & Row, 1983;pp 11-23. 2 Mann JB, Alterman S, Hills AG. Albright's hereditary osteodystrophy comprising 'pseudohypoparathyroidism' and 'pseudopseudohypoparathyroidism'. Ann Intern Med 1 962;56:3 15-39. 3 Drezner M, Neelon FA, Lebovitz HE, et al. 'Pseudopseudohypoparathyroidism' type II. A possible defec...

Summary A case of simultaneous bilateral scapula fractures and a femoral neck fracture of the right hip suffered during hypocalcemic convulsions in a 19-year-old male is presented. The medical history, the treatment, and his latest follow-up are reported. The treatment approaches of such fractures in renal osteodystrophy patients are discussed. Case report A case of simultaneous bilateral scapu...

The widespread use of clhronic dialysis and renal homotransplantation, while prolonging the lives of patients with chronic renal failure, have concomitantly resulted in the appearance of severe disorders of calcium and phosphorus metabolism and disabling renal osteodystrophy (retardation of growth and dwarfism, osteitis fibrosa, rickets or osteomalacia and, at times, osteosclerosis). Furthermor...

Three children with azotaemic renal osteodystrophy were treated with 1,25-dihydroxycholecalciferol (1,25(OH)2D3). All showed clinical, biochemical, and radiological improvement within 6 months of starting treatment. There were no complications. The dose of 1,25(OH)2D3 required was 0-5 microgram per day for 2 children aged 22 and 30 months, and 2 microgram per day for a 15-year-old boy. 2 of the...

In 1960 a 5-year-old girl was found to have developed accelerated hypertension (B.P. 190/150) with blood urea 119 mg/ 100 ml. An intravenous pyelogram showed a small scarred left kidney (5-3 by 32 cm). There was also upper pole scarring with clubbed calyces on the right side. Left nephrectomy was performed and histological examination of the kidney confirmed pyelonephritic changes, and showed i...

Background: Renal osteodystrophy (ROD) is a common bone and mineral metabolism disorder in patients with end-stage renal disease (ESRD). This study aimed to determinate the frequency of the subtypes of ROD and evaluate the diagnostic value of biochemical as the well as radiographic markers for the diagnosis of ROD among hemodialysis patients in Golestan province of Iran.  Materials and Methods...