La viruela símica es una enfermedad zoonótica identificada por primera vez en 1958. El virus un miembro del género Orthopoxvirus, de la familia Poxviridae. Infecta a amplia variedad mamíferos, pero se desconoce su reservorio natural. brote 2022 pertenece los clados IIa y IIb. Es probable que aparición actual deba las importaciones Nigeria 2017-2018. propagación persona puede ocurrir travÃ...

Monkeypox is a zoonotic viral disease that was identified in 1958 research monkeys came from Singapore. It an orthopoxvirus belongs to the Poxviridae family [1]. This infection restricted Africa but last year cases started raising not only rest of world [1,2]. why it became interest; important acknowledge its epidemiological behavior, risks and vaccines, especially recently struck by COVID-19, ...

We report the accidental needlestick inoculation of a laboratory worker with vaccinia virus. Although the patient had previously been vaccinated against smallpox, severe lesions appeared on the fingers. Western blot and polymerase chain reaction-restriction fragment length polymorphism were used to analyze the virus recovered from the lesions. The vaccinia virus-specific immunoglobulin G levels...

Experimental intranasal infection of marmosets (Callithrix jacchus) with calpox virus results in fatal disease. Route and dose used for viral inoculation of the test animals mimics the natural transmission of smallpox, thus representing a suitable model to study pathogenesis and to evaluate new vaccines against orthopoxvirus infection. However, the pathogenic mechanisms leading to death are sti...

Poxviruses belonging to the Orthopoxvirus, Capripoxvirus and Parapoxvirus genera share common host species and create a challenge for diagnosis. Here, we developed a novel multiplex PCR method for the simultaneous detection and differentiation of eight poxviruses, belonging to three genera: cowpox virus (CPXV) and camelpox virus (CMLV) [genus Orthopoxvirus]; goatpox virus (GTPV), sheeppox virus...

Vaccinia virus (VACV) was used as a surrogate of variola virus (VARV) (genus Orthopoxvirus), the causative agent of smallpox, to study Orthopoxvirus infection. VARV is principally transmitted between humans by aerosol droplets. Once inhaled, VARV first infects the respiratory tract where it could encounter surfactant components, such as soluble pattern recognition receptors. Surfactant protein ...

Natural killer (NK) cells provide in vivo control of orthopoxvirus infections in association with their expansion in the draining lymph node (LN), where they are normally very rare. The mechanism of this expansion is unclear. Herein, we determined that NK-cell depletion results in enhanced infection following footpad inoculation of cowpox virus, a natural pathogen of rodents. Following cowpox v...