EVER since he took the first steps towards a conscious life, Man has tried to solve the problems of cosmogony. The most complicated and also the most interesting of these is that of the origin of life. At different times and at different stages of culture different answers have been given. The religious teachings of all ages and peoples have usually attributed the appearance of life to some cre...

A detailed hypothesis for the biogenesis of haouamines is reported herein, supported by experiments headed towards biomimetic synthesis of these compounds.

We have detected a proteolytic mechanism in chloroplasts that selectively and rapidly degrades the imported small subunit of ribulose 1,5-bisphosphate carboxylase when pools of the chloroplast-synthesized large subunit are depleted. This degradation system is constitutively present and appears to be responsible for precise stoichiometric accumulation of the two subunits of the enzyme. We believ...

In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.

The share of increases in life expectancy realized after age 65 was only about 20 percent at the beginning of the 20th century for the US and 16 other countries at comparable stages of development; but that share was close to 80 percent by the dawn of the 21st century, and is almost certainly approaching 100 percent asymptotically. This new demographic transition portends a diminished survival ...

In the first article Impact No. 31, "The Origin of Life A Critique of Early Stage Chemical Evolution Theories," January, 1976) of this series on origin of life theories, following the discussion of problems involved in a naturalistic origin of relatively simple organic compounds, the problem of the origin of large molecules ("macromolecules"), such as the proteins, DNA, and RNA, was introduced....