The major purpose of human biomonitoring is the mapping and assessment exposure to chemicals. European initiative HBM4EU has prioritized seven substance groups two metals relevant for exposure: Phthalates substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- polyfluoroalkyl substances (PFASs), halogenated organophosphorous flame retardants (HFRs OPFRs), polyc...

Characterizing human exposure to pesticides is challenging because their metabolites have a broad diversity of chemical structures. We aimed study the interest associating suspect screening and targeted analysis identify multiple pesticide pregnant women. Approximately 300 urinary samples collected during early pregnancy (France) were analyzed by UHPLC/HRMS using both approach multiresidue anal...

organophosphorous (op) chemical warfare nerve agents mainly sarin and tabun were used during the iran-iraq war with high mortalities. in addition to atropine and oximes, the followings have recently been used successfully for the treatment of op poisoning. 1. sodium bicarbonate: infusion of high doses of sodium bicarbonate (5 meq/kg in 60 min. followed by 5-6 meq/kg/day to obtain arterial blood...

A dual-transducer flow-injection biosensor detection system for monitoring organophosphorus (OP) neurotoxins is described. Such simultaneous use of different physical transducers in connection to the same (organophosphorous hydrolase (OPH)) enzyme enhances the information content and provides discrimination between various subclasses of OP compounds. While the potentiometric biosensor responds ...

Organophosphorous and organochlorine pesticides, which were banned or restricted in the US and in Europe years ago, are still applied in India to control pests affecting pulses and wheat. Their simple application, efficacy, and economic return may explain the popularity of these pesticides in Indian agriculture. Unfortunately, organophosphorous and organochlorine pesticides are in general very ...

Resistance to temephos, an organophosphorous insecticide (OP), was found to be low (2-fold) in 2 Culex pipiens populations collected in Sayada (mid-eastern Tunisia). This resistance was synergized by an esterase inhibitor (DEF). Two sets of over-produced esterases (A2-B2 and A4-B4), known to be involved in resistance, were identified in almost 50% of the examined insects. In addition, 3% of ins...

organophosphorous (op) pesticides are used frequently in agriculture, particularly in asian countries over the past decades. poisoning by these agents, either as acute or chronic in these nations, is a serious health problem. op pesticides residue in fruits and vegetables that may not induce early clinical features, could also affect the human health. therefore, medical and health professionals...