نتایج جستجو برای: organophosphate
تعداد نتایج: 3797 فیلتر نتایج به سال:
The organophosphate pesticides have been used extensively for plant protection; however these chemicals may be toxic to mammals (1,2). Insecticidal action and toxic effect are due to their being potent cholinesterase inhibitors (3,4). Acetylcholine is believed to be the primary transmitter affected by organophosphate insecticides. Although the pesticidal action of organophosphate insecticides h...
BACKGROUND/AIMS Organophosphate poisoning has a high mortality rate. Recently, differences among organophosphorus insecticides in human self-poisoning were reported. This study investigated the prognostic risk factors and the mortality of different organophosphates following acute organophosphate poisoning. METHODS This retrospective study included 68 patients with acute organophosphate poiso...
A challenge in the computational design of enzymes is that multiple properties, including substrate binding, transition state stabilization and product release, must be simultaneously optimized, and this has limited the absolute activity of successful designs. Here, we focus on a single critical property of many enzymes: the nucleophilicity of an active site residue that initiates catalysis. We...
Neutralization represents an important goal in toxicology, reducing exposure to poison being crucial in any management plan of any intoxication. Controversial data actually exists in the literature regarding activated charcoal capacity to bind organophosphates. To determine and compare organophosphate binding capabilities for different hydrophobic substances, considered to have neutralising pro...
background: cardiac manifestations that occur in a majority of patients with organophosphate (op) poisoning may range from innocuous electrocardiographic manifestations, such as sinus tachycardia, to life-threatening complications, including cardiogenic pulmonary edema and myocardial necrosis. in this study, we evaluated the various electrocardiographic manifestations in patients with op poison...
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