Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies (mAbs) with the potency of cytotoxic molecules, thereby taking advantage of the best characteristics of both components. Along with the development of the mAbs and cytotoxins, the design of chemical linkers to covalently bind these building blocks is making rapid progress but remains challenging. Recent advances ha...

The current state-of-the-art Entity Linking (EL) systems are geared towards corpora that are as heterogeneous as the Web, and therefore perform sub-optimally on domain-specific corpora. A key open problem is how to construct effective EL systems for specific domains, as knowledge of the local context should in principle increase, rather than decrease, effectiveness. In this paper we propose the...

Here we describe a general synthetic platform for side-chain macrocyclization of an unprotected peptide library based on the SNAr reaction between cysteine thiolates and a new generation of highly reactive perfluoroaromatic small molecule linkers. This strategy enabled us to simultaneously "scan" two cysteine residues positioned from i, i + 1 to i, i + 14 sites in a polypeptide, producing 98 ma...

Linkers that favor rectification of interfacial electron transfer are likely to be required for efficient photo-driven catalysis of multi-electron reactions at electrode surfaces. Design principles are discussed, together with the synthesis and characterization of a specific pair of molecular linkers, related by inversion of the direction of an amide bond in the heart of the molecule. The linke...

Metal–organic frameworks (MOFs) are composed of metal nodes connected by organic linkers.

Three new carboxylic-acid substituted oligo-phenylenevinylenes (OPVs) with electron-donating substituents in the central ring were synthesized in high yield by the Mizoroki–Heck reaction. The linkers were optically characterized by UV–vis absorption spectrophotometry, fluorescence spectroscopy in solution and the solid state, and measurement of the emission quantum yield. A comparison of substi...

Ion channels are proteins that control the flux of ions across cell membranes by opening and closing (gating) their pores. It has been proposed that channels gated by internal agonists have an intracellular gating ring that extracts free energy from agonist binding to open the gates using linkers that directly connect the gating ring to the gates. Here we find for a voltage- and Ca(2+)-activate...

Single-step fusion-based affinity purification of proteins with pH-controllable linkers was carried out in a fluidic device. The linkers were previously derived from self-splicing protein elements called inteins. Two different linkers were generated to solve two distinct separation problems: one for rapid single-step affinity purification of a wide range of proteins, and the other specifically ...