BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the...

Background and objective:  Oral tongue Squamous Cell carcinoma (SCC) commonly involves males between the sixth to eighth decades of life. Major risk factors are tobacco usage and alcohol consumption. The increasing number of patients developing oral tongue cancer without these well-known risk factors suggests that a viral infection, such as Human Papil...

Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, cont...

background: s-methyl cysteine (smc) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. the purpose of the present study was to investigate the protective effect of smc on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome. methods: male wistar rats were divided into five groups (6 rats in each group), namely; control, con...

lipoma is a benign mesenchymal tumor of fat with uncertain pathogenesis. although the most common mesenchymal neoplasm in trunk and proximal portions of the extremities, it is rarely seen in the oral cavity. oral lipomas are clinically soft, smooth-surfaced nodular masses that mostly are less than 3 cm in size. typically the tumor is asymptomatic unless bitten or become noticeable because of th...

Lipoma is a common tumor of soft tissue. Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal por-tions of extremities. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. The clinical presentation is typically as an...

oral cancer is considered a great threat to public health. tongue cancer accounts for nearly 30% of all oral cancers and usually seen in 50 to 60 year old men. oropharyngeal cancers account for 3% of all cancers in iran; as reported in 2003. the present study was designed to assess the epidemiologic and clinicopathologic characteristics of tongue cancer patients in two tehran's referral univers...

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...

Introduction: Endostatin is a C-­terminal proteolytic fragment of collagen XVIII and, as with angiostatin and thrombospondin, is known as an anti­angiogenic agent. The aim of this study was to assess the level of serum endostatin in patients with oral squamous cell carcinoma (SCC), and its association with the clinicopathological characteristics of the tumor.   Materials and Methods:  Using an ...

BACKGROUND AND PURPOSE Several studies indicated that tumor thickness or tumor volume might be helpful predictors for the prognosis of oral tongue squamous cell carcinoma. Our aim was to compare the value of tumor thickness versus tumor volume measurement based on preoperative MR imaging in predicting the prognosis of oral tongue squamous cell carcinoma, especially focusing on lymph node metast...