Background Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim ...

The most common malignancy of the head and neck region is “oral squamous cell carcinoma” (OSCC) because its low survival rate increasing incidence in some geographic areas. The process invasion metastasis, which noted cancers, requires loss cell-to-cell attachment. It therefore important to identify a marker that would help identification lesions acquire ability transform into OSCC. Cell...

Background: Oral squamous cell carcinoma is a major cause of cancer-related deaths world-wide. Histologically it arises from the benign squamous epithelium lining the oral cavity and is conventionally divided into well, moderate, and poorly differentiated subtypes. Nicotinamide phosphoribosyltransferase catalyses the rate-limiting step of nicotinamide adenine dinucleotide synthesis and is highl...

background: heat shock proteins (hsps) are a family of proteins that are known to play a significant role in the repair of denatured proteins in the cell. it seems that cytoprotective properties of hsps may help in malignant progression by facilitating tumor cell growth and survival. the purpose of this study is to evaluate hsp27 and hsp70 expression in various histopathological grades of squam...

Cervical cancer is the fourth-most universal basis of cancer and decease from cancer in women. An estimated 528,000 cases of cervical cancer occurred, with 266,000 deaths. This is about 8% of the total cases and total deaths from cancer. About 70% of cervical cancers arise in developing countries. In low-income countries, it is the most common cause of cancer death. In the design of an artifici...

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum le...

conclusions based on evidence, dentists and dental health care professionals should consider periodontal disease as a risk factor for the development of neoplasms in the oral cavity. it also seems a good idea to provide periodontal therapy for patients with cancer to achieve ideal therapeutic results. results cancer of the oral cavity and periodontal disease are related from different aspects. ...

The aim of this study is to investigate the effects of cold atmospheric pressure plasma (CAP)-induced radicals on the epidermal growth factor receptor (EGFR), which is overexpressed by oral squamous cell carcinoma, to determine the underlying mechanism of selective killing. CAP-induced highly reactive radicals were observed in both plasma plume and cell culture media. The selective killing effe...

skin cancer has a broad and burdensome impact on the health and well-being of iranian and account for substantial health care costs to the nation. the first most common form of skin cancer is basal cell carcinoma (bcc); followed by the squamous cell carcinoma (scc) and the incidence of malignant melanoma (mm) is lower but is fatal. kaposi sarcoma (ks) is a tumor caused by human herpes virus 8. ...