BACKGROUND Immunosuppressive medications typically used to treat the immunobullous disorders pemphigus vulgaris, pemphigus foliaceous, and bullous pemphigoid can have serious adverse effects. The tetracycline family of antibiotic drugs has been shown to be effective in the treatment of these conditions with a more favorable side effect profile. Minocycline hydrochloride use has been associated ...

BACKGROUND Pemphigus is a common autoimmune blistering disorder in India. However, there are no population based surveys from India available to study the prevalence of this disease. AIMS To estimate the incidence of pemphigus in Thrissur district, Kerala, South India. METHODS Questionnaire based survey was conducted among the practicing dermatologists of Trichur district between 1 st Janua...

Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was assessed by comparing the areas under the serum concentration-time curves foll...

Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was co...

BACKGROUND Mycophenolate mofetil is increasingly being used as a corticosteroid-sparing agent in immunosuppressive regimens. OBJECTIVE To elucidate the effectiveness of mycophenolate as adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. DESIGN Historical prospective study. SETTING University hospital. PATIENTS The study included 42 consecutive patients...

BACKGROUND Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. OBJECTIVES To investigate the potential role of IL-23 in pemphigus vulgaris. METHODS In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion an...

Pemfigus vulgaris (PV) adalah penyakit autoimun vesikobulosa pada kulit dan membran mukosa yang secara histologi ditandai bula intraepidermal disebabkan oleh akantolisis. Steroid sistemik merupakan terapi utama PV. Artikel ini membahas efek samping steroid parenteral pemfigus vulgaris.
 Pemphigus Vulgaris is an autoimmune blistering disease of skin and mucous membranes, histologically defi...

OBJECTIVE (1) To investigate the incidence of laryngeal involvement in a large series of patients with pemphigus vulgaris, using endoscopic examination, (2) to describe the lesions, and (3) to establish a classification of laryngeal involvement in pemphigus vulgaris based on the location of the lesions. STUDY DESIGN Prospective study. METHODS A total of 40 sequentially treated pemphigus vul...

Molecular mechanisms underlying the pathophysiology of pemphigus vulgaris are still not clear. We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. Seventeen patients with active pemphigus vulgaris and 19 normal healthy controls were included in the study. The immu...