We report the occurrence of acute pulmonary edema in a patient receiving therapy with nalbuphine, a synthetic narcotic analgesic. Other potential causes of acute pulmonary edema were excluded. It is likely that all opiate drugs share the propensity to produce acute pulmonary edema, and nalbuphine resembles other opiates in this regard.

Opiates have been commonly used for the management of pain for many years. Despite this, there is a surprising lack of research into the effects of opiates on cognition, with far more research having been carried out on other classes of psychotropic drugs. This paper will outline why it is important to understand the cognitive effects of opiates, in particular the short acting opiates morphine ...

INTRODUCTION Nowadays women constitute one third of all addicts. In the last decade, there has been a remarkable growth in scientific interest in biochemical and psychosocial aspects of women's addiction. Many researches point out the specific character of women's addiction. OBJECTIVE The aim of the study was to assess and compare psychosocial aspects, including the sociodemographic character...

Diverse studies and case reports have recently raised the interest of topiramate in the treatment of addictive disorders such as alcohol dependence [7,8] , opiates [9] and benzodiazepines withdrawal [10], smoking cessation (Khazaal et al in press), but also in other disorders characterized by compulsive behavior like binge eating disorder [11,12], bulimia nervosa [13], obesity [14], Tourette’s ...

We have shown previously that whereas acute exposure of cultured murine peritoneal macrophages inhibits phagocytosis, chronic exposure results in a putative tolerant/dependent state. We now report similar observations using human cultured monocyte-derived macrophages (hMDM) from a control population and from methadone patients. With hMDM, acute exposure to morphine and methadone inhibited phago...