BACKGROUND The spleen is an active lymphoid organ. The effect of splenectomy on the immune response remains unclear. This study investigated whether splenectomy can induce immune tolerance and has a beneficial role in cardiac allograft. METHODS Wistar rats were used for heart donors. The Sprague-Dawley (SD) rats designated as the recipients of heart transplantation (HT) were randomly assigned...

OBJECTIVE To determine whether laparoscopic splenectomy (LS) is a safe, cost-effective alternative to open splenectomy (OS). DESIGN Retrospective comparison and economic evaluation. SETTING Tertiary care children's hospital. PATIENTS Children with hematologic disease involving the spleen. INTERVENTIONS Laparoscopic splenectomy (10 patients); OS (10 patients). MAIN OUTCOME MEASURES Saf...

Patients undergoing splenectomy have an increased risk of splenic/portal vein thrombosis. We used several databases to identify publications dealing with this risk and analyzed incidence, risk factors and outcome. The risk of splenic portal vein thrombosis has been addressed in prospective and retrospective randomized or non-randomized studies. All studies combined, the overall risk is 3.3%. Ri...

Objective- To assess the feasibility of splenectomy using intracorporeal ligature placement technique. Design- Randomized experimental study. Animals- Dogs (n=7) weighting≥ 20 kg. Procedures- Dogs were randomly selected. A lap-assisted splenectomy was performed. The feasibility of splenectomy was examined using intracorporeal ligatures. Comparisons were made regarding the anes...

spleen is a major component of the reticuloendothelial system and functions as a filtering system for the encapsulated bacteria especially in children. knowing the spectrum of conditions leading to splenectomy in any geographic area is important to decrease the number of unnessesary splenectomies. here we report the causes of splenectomy in three major general referring hospitals in shiraz, the...

a rare case of splenic harmartoma in a 31 year old female is reported. she was admitted with splenomegaly, fever and chronic history of epistaxis. routine hematological survey revealed pancytopenia and mild hypercellular marrow. abdominal sonography showed a space-occupying lesion in the spleen which was suspected as malignant tumor. splenectomy was performed and histologic findings were diagno...

HYPOTHESIS The incidence of primary lymphoma of the spleen in patients with idiopathic splenomegaly is significant. DESIGN Retrospective review of all patients referred to a general surgical service for splenectomy. SETTING A large tertiary care hospital. PATIENTS Between 1994 and 2001, 86 nontrauma patients were referred for splenectomy. Of these, 18 had idiopathic splenomegaly despite p...

INTRODUCTION Primary splenic malignant lymphoma is quite a rare disease, and its preoperative diagnosis is difficult. CASE PRESENTATION An 80-year-old man was diagnosed with advanced rectosigmoid cancer with liver and splenic metastases, for which he underwent single-incision laparoscopic high anterior resection for the primary rectosigmoid cancer. After chemotherapy, he underwent laparoscopy...

OBJECTIVES Little is known about the risk of pyogenic liver abscess in patients with splenectomy. We explored the relationship between splenectomy and pyogenic liver abscess in Taiwan. METHODS We conducted a nationwide cohort analysis using the hospitalization dataset of the Taiwan National Health Insurance Program. We included 17,779 subjects aged 20-84 years who underwent splenectomy in 199...

In this paper we present a rare case of splenic rupture that occurred after an open aortic valve replacement in a male patient with hemangiomatosis of the spleen and the liver. The patient was treated with an emergency splenectomy. He showed no other sings of associated systemic disorder, such as Klippel-trénaunay syndrome or Proteus syndrome.